Heme Oxygenase-1 in Macrophages Impairs the Perfusion Recovery After Hindlimb Ischemia by Suppressing Autolysosome-Dependent Degradation of NLRP3

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Bibliographic Details
Published inArteriosclerosis, thrombosis, and vascular biology Vol. 41; no. 5; pp. 1710 - 1723
Main Authors Ma, Yuankun, Jia, Liangliang, Wang, Yidong, Ji, Yongli, Chen, Jian, Ma, Hong, Lin, Xiaoping, Zhang, Yuhao, Li, Wudi, Ni, Hui, Xie, Lan, Xie, Yao, Xiang, Meixiang
Format Journal Article
LanguageEnglish
Published United States 05.05.2021
Subjects
Animals
Cells, Cultured
Databases, Genetic
Disease Models, Animal
Heme Oxygenase-1 - genetics
Heme Oxygenase-1 - metabolism
Hindlimb
Humans
Inflammasomes - genetics
Inflammasomes - metabolism
Inflammation Mediators - metabolism
Ischemia - enzymology
Ischemia - genetics
Ischemia - physiopathology
Lysosomes - enzymology
Macrophages - enzymology
Male
Membrane Proteins - genetics
Membrane Proteins - metabolism
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle, Skeletal - blood supply
Muscle, Skeletal - enzymology
Muscle, Skeletal - physiopathology
Neovascularization, Physiologic
NLR Family, Pyrin Domain-Containing 3 Protein - genetics
NLR Family, Pyrin Domain-Containing 3 Protein - metabolism
Proteolysis
Recovery of Function
Regional Blood Flow
macrophage
perfusion
heme oxygenase-1
mice
hindlimb ischemia
inflammasome
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Summary:[Figure: see text].
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1079-5642
1524-4636
DOI:10.1161/ATVBAHA.121.315805