Probing Tumour Proteostasis and the UPR with Serum Markers

Tumour proteostasis and the unfolded protein response (UPR) are emerging drivers of tumour progression and important determinants of clinical efficacy of cancer therapy. Recent findings indicate that they also regulate the production of protein tumour markers. Here, we discuss how this new knowledge...

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Bibliographic Details
Published inTrends in cancer Vol. 2; no. 5; p. 219
Main Authors Galmiche, Antoine, Sauzay, Chloé, Houessinon, Aline, Chauffert, Bruno, Pluquet, Olivier
Format Journal Article
LanguageEnglish
Published United States 01.05.2016
Subjects
Biomarkers - blood
Humans
Neoplasms - blood
Neoplasms - drug therapy
Neoplasms - metabolism
Proteostasis
Unfolded Protein Response
serum tumour markers
therapeutics
tumour proteostasis
UPR
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Summary:Tumour proteostasis and the unfolded protein response (UPR) are emerging drivers of tumour progression and important determinants of clinical efficacy of cancer therapy. Recent findings indicate that they also regulate the production of protein tumour markers. Here, we discuss how this new knowledge opens up new perspectives for cancer therapeutics.
ISSN:2405-8025
DOI:10.1016/j.trecan.2016.04.004