Differences in the relation between bone mineral content and lean body mass according to gender and reproductive status by age ranges

• Published in: Journal of bone and mineral metabolism Vol. 37; no. 4; pp. 749 - 758
• Main Authors: Denova-Gutiérrez, Edgar, Clark, Patricia, Capozza, Ricardo Francisco, Nocciolino, Laura Marcela, Ferretti, Jose Luis, Velázquez-Cruz, Rafael, Rivera, Berenice, Cointry, Gustavo Roberto, Salmerón, Jorge
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.07.2019; Springer Nature B.V
• Subjects: Absorptiometry; Adolescent; Adult; Age; Age Factors; Aged; Aged, 80 and over; Body Composition; Body mass; Body Weight; Bone Density; Bone mass; Bone mineral content; Child; Cohort Studies; Cross-Sectional Studies; Dual energy X-ray absorptiometry; Female; Health Personnel; Humans; Lean body mass; Male; Medical personnel; Medicine; Medicine & Public Health; Metabolic Diseases; Middle Aged; Original Article; Orthopedics; Post-menopause; Reference Values; Reproduction; Reproductive status; Sex Characteristics; Thinness - physiopathology; Workers; Young Adult; Bone mineral content; Lean mass; Tanner stage; Muscle–bone relation
• ISSN: 0914-8779; 1435-5604; 1435-5604
• DOI: 10.1007/s00774-018-0978-0

The present study aims: (1) to explore the influence of lean mass (LM) on bone mineral content (BMC), (2) to investigate the pubertal influences on the BMC–LM relation, and (3) to perform Z -score charts of BMC–LM relation, stratified by gender and reproductive status categorized by age ranges. A cross-sectional analysis was conducted using 4001 healthy subjects between 7 and 90 years participating in the Health Workers Cohort Study. Of these, 720 participants were ≤ 19 years, 2417 were women ≥ 20 years, and 864 were men ≥ 20 years. Using Dual X-ray absorptiometry (DXA), we measured BMC and LM. Participants’ pubertal development was assessed according to Tanner’s stage scale. To describe BMC–LM relation, simple correlation coefficients were computed. To produce best-fit equations, an ANOVA test was conducted. Z -score graphs for the BMC–LM relation were obtained. In general, the BMC–LM correlations were linear and highly significant. For boys, curves were virtually parallel, with similar intercepts and a progressive displacement of values toward the upper-right region of the graph, for each Tanner subgroup. For girls, curves for Tanner 1-2 and 4-5 stages were parallel; but, in girls Tanner 4-5, the intercepts were significantly higher by about +300–400 g of BMC ( P  < 0.001). For postmenopausal women, the curve was parallel to that for the premenopausal but showed a lower intercept ( P  < 0.001). We provide DXA reference data on a well-characterized cohort of 4001 healthy subjects. These reference curves provide a reference value for the assessment and monitoring of bone health in all age groups included in the present study.