Association of variants on ADIPOQ and AdipoR1 and the prognosis of gastric cancer patients after gastrectomy treatment

• Published in: Molecular biology reports Vol. 42; no. 2; pp. 355 - 361
• Main Authors: Wu, Xuming, Chen, Peizhan, Ou, Yiyi, Liu, Jibin, Li, Chenglin, Wang, Hui, Qiang, Fulin
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer-Verlag 01.02.2015; Springer Netherlands; Springer Nature B.V
• Subjects: adipocytes; adiponectin; Adiponectin - genetics; adiponectin receptors; Aged; alcohol drinking; Alleles; Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; carcinogenesis; chemotherapy; Female; Gastrectomy; Gastric cancer; genes; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Genotype; Histology; Humans; insulin; Life Sciences; Male; Medical prognosis; Middle Aged; Molecular biology; Morphology; mortality; Neoplasm Staging; patients; Polymorphism, Single Nucleotide; Prognosis; Proportional Hazards Models; Proteins; Receptors, Adiponectin - genetics; Risk Factors; signal transduction; stomach neoplasms; Stomach Neoplasms - diagnosis; Stomach Neoplasms - genetics; Stomach Neoplasms - mortality; Stomach Neoplasms - surgery; Surgery; Adiponectin receptor 1; Overall survival; Gastric cancer; Adiponectin
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-014-3775-4

Adiponectin is a protein hormone secreted exclusively by adipocytes and it is responsible for insulin sensitization in the human body. Deregulation of adiponectin and its downstream signaling pathway genes have been found to be involved in the gastric cancer carcinogenesis; however, whether the variants on adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) affect the prognosis of gastric cancer patients are still unknown. Here we have recruited 455 gastric cancer patients, who have received the gastrectomy treatment to evaluate the prognostic effects of variants on ADIPOQ (rs266729 and rs822395) and AdipoR1 (rs12733285 and rs1342387) for the gastric cancer patients. No significant association between the four variants and the overall survival of the gastric cancer patients was found. However, for those patients without a previous history of alcohol drinking, the rs266729 GG/CG genotype carriers showed a significantly decreased gastric cancer mortality compared to homogeneity CC patients (HR 0.74, 95 % CI 0.56–0.97; p = 0.032) after adjustment for variants age, sex, smoking status, tumor stage, tumor location and post-surgery chemotherapy. No significant association between the variant rs266729 genotypes and overall survival for the gastric cancer patients with an alcohol drinking habit. These data suggested that the variant rs266729 was an independent prognostic factor for the never drinking gastric cancer patients who received surgical treatment.