Transcriptome profiling of human papillary and reticular fibroblasts from adult interfollicular dermis pinpoints the ‘tissue skeleton’ gene network as a component of skin chrono-ageing

• Published in: Mechanisms of ageing and development Vol. 179; pp. 60 - 77
• Main Authors: Haydont, Valérie, Neiveyans, Véronique, Fortunel, Nicolas O., Asselineau, Daniel
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2019
• ISSN: 0047-6374; 1872-6216; 1872-6216
• DOI: 10.1016/j.mad.2019.01.003

•This work is about dermal Fp and Fr fibroblasts from young and old human skin.•Age-related biomarkers were identified by genome-wide transcriptome profiling.•Ageing affects ‘tissue skeleton’ transcripts levels, even more in Fr than in Fp.•Nuclear circularity decreases with ageing in both Fp and Fr...