Significant association of IL-6-572G/C, IL-6-597G/A, and IL-6-174G/C polymorphisms and susceptibility to lumbar degenerative disease: A meta-analysis

• Published in: Clinical neurology and neurosurgery Vol. 175; pp. 40 - 46
• Main Authors: Gao, Shu-tao, Xu, Tao, Xun, Chuan-hui, Liang, Wei-dong, Cao, Rui, Mao, Cao, Sheng, Wei-bin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2018; Elsevier Limited
• Subjects: Cytokines; Ethnicity; Genes; Health risks; Interleukin 6; Lumbar degenerative disease; Meta-analysis; Neurology; Polymorphism; Studies; Systematic review; China; Finland; Lumbar degenerative disease; Polymorphism; Interleukin-6; Meta-analysis
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2018.10.004

•IL-6-572 G/C, IL-6-597 G/A, and IL-6-174 G/C polymorphisms are significantly associated with LDD.•G-allele carriers of IL-6-572 G/C, IL-6-597 G/A, and IL-6-174 G/C appear to have an increased risk of LDD.•Researches among more ethnicities are needed for a better understanding of the etiology of LDD. To assess and synthesize the current evidence on the association of interleukin-6 (IL-6)-572 G/C, IL-6-597 G/A, and IL-6-174 G/C polymorphisms and risk of lumbar degenerative disease (LDD). Five electronic databases including PubMed, EMBASE, Web of Science, CNKI and Wanfang were systematically searched for potential studies previous to August 10, 2018. Summary odds ratio (OR) and corresponding 95% confidence interval (95%CI) were calculated to evaluate the association. Nine case-control studies comprising 1519 cases and 1887 controls were obtained for the meta-analysis. For IL-6-572 G/C, IL-6-597 G/A, and IL-6-174 G/C polymorphisms, there were seven, six, and seven studies eventually included in the meta-analysis respectively. The findings indicated that the three polymorphisms had significant associations with risk of LDD: for IL-6-572 G/C, G vs. C, OR = 1.37, 95%CI 1.11–1.69, P = 0.004; for IL-6-597 G/A, G vs. A, OR = 1.38, 95 %CI 1.16–1.65, P = 0.000; for IL-6-174 G/C, G vs. C, OR = 1.63, 95%CI 1.15–2.29, P = 0.006. The present meta-analysis found IL-6-572 G/C, IL-6-597 G/A, and IL-6-174 G/C polymorphisms were significantly associated with increased risk of LDD susceptibility.