Percutaneous ablation of pancreatic cancer

Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in c...

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Bibliographic Details
Published inWorld journal of gastroenterology : WJG Vol. 22; no. 44; pp. 9661 - 9673
Main Authors D'Onofrio, Mirko, Ciaravino, Valentina, De Robertis, Riccardo, Barbi, Emilio, Salvia, Roberto, Girelli, Roberto, Paiella, Salvatore, Gasparini, Camilla, Cardobi, Nicolò, Bassi, Claudio
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 28.11.2016
Subjects
Ablation Techniques - adverse effects
Ablation Techniques - mortality
Carcinoma, Pancreatic Ductal - mortality
Carcinoma, Pancreatic Ductal - pathology
Carcinoma, Pancreatic Ductal - surgery
Catheter Ablation
Chemotherapy, Adjuvant
Cryosurgery
Electroporation
Humans
Microwaves - therapeutic use
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Postoperative Complications - etiology
Radiotherapy, Adjuvant
Risk Factors
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Microwave ablation
Pancreatic cancer
Pancreatic adenocarcinoma
Radiofrequency ablation
Cryoablation
Ablation treatment
Percutaneous treatment
Irreversible electroporation
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Summary:Pancreatic ductal adenocarcinoma is a highly aggressive tumor with an overall 5-year survival rate of less than 5%. Prognosis and treatment depend on whether the tumor is resectable or not, which mostly depends on how quickly the diagnosis is made. Chemotherapy and radiotherapy can be both used in cases of non-resectable pancreatic cancer. In cases of pancreatic neoplasm that is locally advanced, non-resectable, but non-metastatic, it is possible to apply percutaneous treatments that are able to induce tumor cytoreduction. The aim of this article will be to describe the multiple currently available treatment techniques (radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation), their results, and their possible complications, with the aid of a literature review.
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Author contributions: D’Onofrio M and Ciaravino V contributed to the study idea, study design, study cases, manuscript preparation, and references; D’Onofrio M contributed to manuscript review and manuscript approval; De Robertis R, Barbi E, Salvia R, Girelli R, and Paiella S contributed to study cases; Gasparini C and Cardobi N contributed to the references; Bassi C contributed to manuscript review.
Correspondence to: Mirko D’Onofrio, Professor, Department of Radiology, G.B. Rossi Hospital, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy. mirko.donofrio@univr.it
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v22.i44.9661