Differences in the association between glycemia and uric acid levels in diabetic and non-diabetic populations

• Published in: Journal of diabetes and its complications Vol. 33; no. 8; pp. 511 - 515
• Main Authors: Kuo, Kuan-Ting, Chang, Yin-Fan, Wu, I-Hsuan, Lu, Feng-Hwa, Yang, Yi-Ching, Wu, Jin-Shang, Chang, Chih-Jen
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2019; Elsevier Limited
• Subjects: Blood pressure; Body mass index; Cholesterol; Confidence intervals; Diabetes; Diabetes mellitus; Fasting; Glucose; Glucose tolerance; Hypertension; Metabolism; Oxidative stress; Smoking; Uric acid; United States > US; Glucose tolerance; Oxidative stress; Glucose; Uric acid; Diabetes mellitus
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2019.05.004

Our study aimed to investigate the influence of different glycemic statuses and their fasting plasma glucose/2-hour post-load glucose on uric acid level. A total of 14,787 subjects were recruited after excluding subjects with medication for hyperuricemia or diabetes. Fasting plasma glucose (FPG), 2-hour post-load glucose (2hPG), and uric acid (UA) were measured. Then, subjects were divided into normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes. After adjustment for clinical variables, in NGT group, there was no significant relationship found between UA level and FPG. However, there was a positive association between UA level and 2hPG (β = 0.003, 95% CI: 0.002~0.004). A similar trend was also observed between UA level and 2hPG in IFG group (β = 0.004, 95% CI: 0.000~0.009) and IGT group (β = 0.005, 95% CI: 0.002~0.008), but relationship between UA level and FPG remained insignificant. In diabetes group, UA level was negatively associated with both FPG (β = −0.008, 95% CI: −0.010 ~ −0.007) and 2hPG (β = −0.005, 95% CI: −0.006 ~−0.003). In non-diabetic individuals, UA level increased with 2hPG, but not with FPG, and UA level was inversely associated with both FPG and 2hPG in diabetic population.