In vitro degradation of poly (L-co-D,L lactic acid) containing PCL-T

The application of polymer-based bioresorbable temporary devices in the medical field grows continuously, and professionals from several areas act to solve problems related to body functions lost due to diseases, accidents or natural wear. Here we study the influence from poly(caprolactonetriol) (PC...

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Bibliographic Details
Published inPolímeros Vol. 24; no. 1; pp. 1 - 8
Main Authors Marcia Adriana Tomaz Duarte, Eliana Aparecida de Rezende Duek, Adriana Cristina Motta
Format Journal Article
LanguageEnglish
Published Associação Brasileira de Polímeros 01.01.2014
Subjects
Bioresorbable polymer
in vitro degradation
PLDLA/PCL-T
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Summary:The application of polymer-based bioresorbable temporary devices in the medical field grows continuously, and professionals from several areas act to solve problems related to body functions lost due to diseases, accidents or natural wear. Here we study the influence from poly(caprolactonetriol) (PCL-T) on the degeneration process in the copolymer poly(L-co-DL-lactic acid) (PLDLA) membrane, by producing PLDLA/PCL-T blends with 90/10, 70/30 and 50/50 relative concentrations. The data for in vitro degradation showed that PCL-T decreases the rate of PLDLA. This was obtained with the following techniques: Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Gel Permeation Chromatography (GPC) and Scanning Electron Microscopy (SEM). Therefore, it is possible to vary the membrane degradation rate by changing the blend composition, which is a tool to tailor a biomaterial.
ISSN:1678-5169
DOI:10.4322/polimeros.2014.056