Histone deacetylase 8 regulates NF-κB-related inflammation in asthmatic mice through H3K9 acetylation

• Published in: Chinese medical journal Vol. 135; no. 17; pp. 2110 - 2112
• Main Authors: Ren, Yuan, Li, Menglu, Bai, Shiyao, Su, Xinming
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins Ovid Technologies 05.09.2022; Wolters Kluwer
• Subjects: Acetylation; Animals; Anthrax; Apoptosis; Asthma; Cytokines; Epigenetics; Gene expression; Histone Deacetylase Inhibitors; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Inflammation; Laboratory animals; Mice; NF-kappa B - metabolism; Pathogenesis; United States > US; China
• ISSN: 0366-6999; 2542-5641
• DOI: 10.1097/CM9.0000000000001963

Quantitative analysis revealed that the expression level and enzymatic activity of HDAC8 decreased significantly under inhibition by dexamethasone or PCI-34051 in asthmatic lung tissue [Figure 1C and 1D]. Previous studies have shown that the NF-κB signaling pathway is activated during the inflammatory response in asthma, and that NF-κB-related inflammatory gene expression is closely related to the acetylation level of the H3K9 site. Using the high performance liquid chromatography method, Aramsangtienchai et al[4] found that HDAC8 could regulate the acetylation levels of histones at H3K9, H2BK12, and H3K18 and affect downstream gene transcription. [6] Among such histone modification sites (H3K9, H3K14, H3K18, H3K27, H3K36, and others), the acetylation and methylation modifications of H3K9 directly participate in and regulate the transcription of NF-κB-dependent inflammatory genes. [...]it is speculated that the anti-inflammatory function of HDAC8 inhibitors may be exerted via the regulation of H3K9 acetylation and modulation of the level of stimulation by the NF-κB pathway.