Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment

Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC re...

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Published inWorld journal of gastroenterology : WJG Vol. 26; no. 18; pp. 2126 - 2137
Main Authors Qiu, Li-Wei, Liu, Yi-Fei, Cao, Xiao-Qing, Wang, Yan, Cui, Xiao-Hong, Ye, Xian, Huang, Shuo-Wen, Xie, Hong-Jun, Zhang, Hai-Jian
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 14.05.2020
Subjects
Animals
Annexin A2 - metabolism
Biomarkers, Tumor - metabolism
Carcinogenesis - immunology
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Disease Models, Animal
Disease Progression
Gene Expression Regulation, Neoplastic - immunology
Humans
Liver - immunology
Liver - pathology
Liver Neoplasms - genetics
Liver Neoplasms - immunology
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Opinion Review
Prognosis
Rats
T-Lymphocytes, Regulatory - immunology
Tumor Escape
Tumor Microenvironment - immunology
Up-Regulation
Immune microenvironment
Hepatocellular carcinoma
Checkpoint
Chemotherapy resistance
Annexin A2
Overall survival
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Summary:Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a dismal prognosis, especially when diagnosed at advanced stages. Annexin A2 (ANXA2), is found to promote cancer progression and therapeutic resistance. However, the underlining mechanisms of ANXA2 in immune escape of HCC remain poorly understood up to now. Herein, we summarized the molecular function of ANXA2 in HCC and its relationship with prognosis. Furthermore, we tentatively elucidated the underlying mechanism of ANXA2 immune escape of HCC by upregulating the proportion of regulatory T cells and the expression of several inhibitory molecules, and by downregulating the proportion of natural killer cells and dendritic cells and the expression of several inhibitory molecules or effector molecules. We expect a lot of in-depth studies to further reveal the underlying mechanism of ANXA2 in immune escape of HCC in the future.
Bibliography:Corresponding author: Hai-Jian Zhang, MD, PhD, Associate Professor, Doctor, Postdoc, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong 226001, Jiangsu Province, China. hjzhang@ntu.edu.cn
Author contributions: Qiu LW, Liu YF, and Cao XQ designed the research study, conducted the experiments, analyzed the data, and wrote the paper; Wang Y, Cui XH, Xian Ye, Huang SW, and Xie HJ collected the data and reviewed the manuscript; Zhang HJ is the guarantor; Qiu LW, Liu YF, and Cao XQ contributed equally to this work.
Supported by the National Natural Science Foundation of China, No. 81401988; China Postdoctoral Science Foundation, No. 2019M661907; Jiangsu Postdoctoral Science Foundation, No. 2019K159 and No. 2019Z153; General Project of Jiangsu Provincial Health Committee, No. H2019101.
ISSN:1007-9327
2219-2840
DOI:10.3748/WJG.V26.I18.2126