p53 in embryonic development: maintaining a fine balance

In addition to its role as a tumour suppressor and cell-cycle checkpoint control protein, p53 has been implicated as an important protein in embryonic development. Despite the viability of most p53 null mice, evidence has accumulated that p53 may regulate differentiation and the response of embryoni...

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Published inCellular and molecular life sciences : CMLS Vol. 55; no. 1; pp. 38 - 47
Main Authors Choi, J, Donehower, L. A
Format Journal Article
LanguageEnglish
Published Switzerland Springer-Verlag 1999
Springer Nature B.V
Birkhäuser-Verlag
Subjects
abnormal development
Animals
Animals, Genetically Modified
cell cycle
Cell Differentiation - genetics
Disease Models, Animal
embryogenesis
Embryonic and Fetal Development
Embryonic growth stage
Environmental stress
Gene Expression Regulation, Developmental - genetics
Genetics
Mice
Mice, Knockout
neoplasms
Proteins
risk
Rodents
Teratogens - metabolism
Tumor Suppressor Protein p53 - genetics
viability
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Summary:In addition to its role as a tumour suppressor and cell-cycle checkpoint control protein, p53 has been implicated as an important protein in embryonic development. Despite the viability of most p53 null mice, evidence has accumulated that p53 may regulate differentiation and the response of embryonic cells to diverse environmental stresses. Moreover, it appears that maintenance of a fine balance of p53 protein levels within embryonic cells is important for optimal development. Inappropriate overexpression or underexpression of p53 can lead to embryonic lethality or increased risk of malformations. The p53 protein may utilize multiple functional activities in its regulation of developmental processes.
Bibliography:http://dx.doi.org/10.1007/s000180050268
ISSN:1420-682X
1420-9071
DOI:10.1007/s000180050268