Overt bone metastasis and bone marrow micrometastasis of early gastric cancer

Recently we encountered two cases of early gastric cancer (EGC) with bone metastasis after surgery. As they were not accompanied by overt liver, lung, or peritoneal metastasis, we examined the clinical significance of bone metastasis in EGC and its mechanisms by a review of the literature. We found...

Full description

Saved in:
Bibliographic Details
Published inSurgery today (Tokyo, Japan) Vol. 41; no. 2; pp. 169 - 174
Main Authors Ubukata, Hideyuki, Motohashi, Gyou, Tabuchi, Takanobu, Nagata, Hiroyuki, Konishi, Satoru, Tabuchi, Takafumi
Format Journal Article
LanguageEnglish
Published Japan Springer Japan 01.02.2011
Subjects
Bone Marrow Neoplasms - secondary
Bone Neoplasms - secondary
Humans
Medicine
Medicine & Public Health
Review Article
Stomach Neoplasms - pathology
Surgery
Surgical Oncology
Dormancy
Bone metastasis
Early gastric cancer
Sentinel node concept
Micrometastasis
Cascade hypothesis
Stem cell theory
Online AccessGet full text

Cover

More Information
Summary:Recently we encountered two cases of early gastric cancer (EGC) with bone metastasis after surgery. As they were not accompanied by overt liver, lung, or peritoneal metastasis, we examined the clinical significance of bone metastasis in EGC and its mechanisms by a review of the literature. We found only 10 cases of EGC complicated with overt bone metastasis in the English literature, so we also examined the Japanese reports of such cases. The main histologic type of cases of bone metastasis from EGC was the diffuse type, and there were long intervals between surgery and overt bone metastasis. One reason for such long intervals may have been the tumor dormancy. Two types of dormancy, dynamic and static, and two types of postoperative overt metastases, that of micrometastatic origin (normograde metastatic process) and that of bone marrow origin (retrograde metastatic process), were considered. We speculated that there may be specific routes by which the cancer cells infiltrate the bone marrow directly from EGC or lymph node metastasis. The procedures for diagnosing bone micrometastasis using monoclonal antibodies have recently been improved, but their accuracy rates are still not universally accepted. New, more reliable examinations are required to improve the survival rates of EGC.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-010-4389-7