Myo-inositol in assisted reproductive technology from bench to bedside

Inositols are insulin-sensitizing compounds of promising efficacy in the management of polycystic ovary syndrome (PCOS). On the one hand, myo-inositol (myo-ins) plays a regulatory role in male and female reproductive function, influencing the development of oocytes, spermatozoa, and embryos. On the...

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Published inTrends in endocrinology and metabolism Vol. 35; no. 1; pp. 74 - 83
Main Authors Etrusco, Andrea, Laganà, Antonio Simone, Chiantera, Vito, Buzzaccarini, Giovanni, Unfer, Vittorio
Format Journal Article
LanguageEnglish
Published United States 01.01.2024
Subjects
Female
Humans
Inositol - therapeutic use
Insulin
Male
Oocytes
Polycystic Ovary Syndrome - drug therapy
Reproductive Techniques, Assisted
in vitro fertilization
assisted reproductive technology
D-chiro-inositol
infertility
myo-inositol
polycystic ovary syndrome
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Summary:Inositols are insulin-sensitizing compounds of promising efficacy in the management of polycystic ovary syndrome (PCOS). On the one hand, myo-inositol (myo-ins) plays a regulatory role in male and female reproductive function, influencing the development of oocytes, spermatozoa, and embryos. On the other hand, high concentrations of D-chiro-inositol (D-chiro-ins) in the ovary may adversely affect oocyte quality. This review analyses the available literature, which encourages the clinical use of myo-ins in assisted reproductive technologies (ARTs) due to its beneficial effects on female and male reproduction.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2023.09.005