Small Cell Undifferentiated Carcinoma of the Submandibular Gland with Neuroendocrine Features

This article reports the clinical, histopathologic, and immunohistochemical findings in a case of small cell undifferentiated carcinoma of the submandibular gland. The tumor was composed of anaplastic cells slightly larger than lymphocytes without ductal differentiation. On immunohistochemical analy...

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Published inAnnals of otology, rhinology & laryngology Vol. 113; no. 1; pp. 55 - 59
Main Authors de Vicente Rodríguez, Juan Carlos, Forcelledo, Manuel F. Fresno, Vallejo, Gonzalo Hernández, Gutiérrez, Luis M. Junquera, Arranz, Juan S. López
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2004
Annals Publishing Compagny
SAGE PUBLICATIONS, INC
Subjects
Biological and medical sciences
Carcinoma, Small Cell - chemistry
Carcinoma, Small Cell - diagnosis
Carcinoma, Small Cell - pathology
Chromogranins - analysis
Diagnosis, Differential
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Neuroendocrine Tumors - pathology
Otorhinolaryngology. Stomatology
Phosphopyruvate Hydratase - analysis
Submandibular Gland Neoplasms - chemistry
Submandibular Gland Neoplasms - diagnosis
Submandibular Gland Neoplasms - pathology
Synaptophysin - analysis
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
small cell undifferentiated carcinoma
salivary gland neoplasm
immunohistochemistry
Case study
Human
Immunohistochemistry
Anatomic pathology
Stomatology
Submandibular gland
Malignant tumor
Small cell carcinoma
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Summary:This article reports the clinical, histopathologic, and immunohistochemical findings in a case of small cell undifferentiated carcinoma of the submandibular gland. The tumor was composed of anaplastic cells slightly larger than lymphocytes without ductal differentiation. On immunohistochemical analysis, the tumor contained cells that reacted positively with antibodies to cytokeratin, neuron-specific enolase, synaptophysin, and chromogranin. The present case supports the hypothesis that small cell undifferentiated carcinomas of the salivary glands arise from presumed multipotential ductal stem cells. When this tumor entity is located on the salivary glands, it appears to behave less aggressively than when it is a primary tumor of the bronchial tree.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0003-4894
1943-572X
DOI:10.1177/000348940411300113