Impact of the triglyceride level on coronary plaque components in female patients with coronary artery disease treated with statins

• Published in: Heart and vessels Vol. 33; no. 10; pp. 1175 - 1184
• Main Authors: Yamashita, Motoki, Iwata, Atsushi, Kato, Yuta, Futami, Makito, Imaizumi, Satoshi, Kuwano, Takashi, Ike, Amane, Sugihara, Makoto, Nishikawa, Hiroaki, Zhang, Bo, Yasunaga, Shin’ichiro, Saku, Keijiro, Miura, Shin-ichiro
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.10.2018; Springer Nature B.V
• Subjects: Arteriosclerosis; Atherosclerosis; Backscattering; Biomedical Engineering and Bioengineering; Cardiac Surgery; Cardiology; Cardiovascular disease; Cholesterol; Coronary artery; Coronary artery disease; Coronary vessels; Females; Gender aspects; Health risks; Heart diseases; Lipids; Low density lipoprotein; Males; Medicine; Medicine & Public Health; Original Article; Patients; Plaques; Regression analysis; Risk analysis; Risk factors; Sex differences; Statins; Ultrasound; Vascular Surgery; Coronary plaque; Triglyceride; Intravascular ultrasound; Gender difference
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-018-1173-x

Several studies have reported that elevated triglyceride (TG) levels may be more strongly associated with an increased risk of coronary artery disease (CAD) in females than in males. We examined gender differences in the relationship between TG levels and coronary atherosclerosis using integrated backscatter intravascular ultrasound (IB IVUS) in CAD patients treated with statins. Three hundred seventy-eight CAD patients (105 females and 273 males) who underwent percutaneous coronary intervention using IB IVUS, and who were already receiving statin treatment, were included. Gray-scale and IB IVUS examinations were performed for the non-culprit segment of a coronary artery and fasting serum TG concentrations were measured. We found that TG levels were significantly correlated with increased lipid ( r  = 0.40, p  < 0.001) and decreased fibrous ( r  = − 0.37, p  < 0.001) plaque components in females, but not in males. Low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels were not related to either the gray-scale or IB IVUS parameters in both genders. After adjustment for conventional coronary risk factors by a multivariate stepwise regression analysis, higher TG levels in females were independently associated with increased lipid ( β  = 0.31, p < 0.001) contents in coronary plaques. In conclusion, among CAD patients treated with statins, TG levels were associated with lipid-rich coronary plaques in females, but not in males. TG levels may be more important indicators of residual risk after statin treatment in females than in males.