Distribution of selenium and glutathione peroxidase in blood fractions from humans, rhesus and squirrel monkeys, rats and sheep

The distribution of selenium and glutathione peroxidase (GSH-Px) was investigated in blood fractions from humans, rhesus and squirrel monkeys, sheep and rats by gel filtration (Sephadex G-150). The majority of selenium in plasma and erythrocytes from sheep, squirrel monkeys and rats cochromatographe...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 113; no. 11; pp. 2138 - 2146
Main Authors Beilstein, M A, Whanger, P D
Format Journal Article
LanguageEnglish
Published United States 01.11.1983
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Summary:The distribution of selenium and glutathione peroxidase (GSH-Px) was investigated in blood fractions from humans, rhesus and squirrel monkeys, sheep and rats by gel filtration (Sephadex G-150). The majority of selenium in plasma and erythrocytes from sheep, squirrel monkeys and rats cochromatographed with GSH-Px. In contrast, selenium in plasma from humans and rhesus monkeys cochromatographed with two non-GSH-Px proteins and nearly all of the selenium in erythrocytes cochromatographed with the hemoglobin peak. A significant amount of GSH-Px activity in rhesus monkey and human erythrocytes also cochromatographed with the hemoglobin fraction, but very little GSH-Px coeluted with hemoglobin from squirrel monkeys, ovine and rat blood. The results suggest that GSH-Px activity may not be a good measure of selenium status in higher primates.
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ISSN:0022-3166
DOI:10.1093/jn/113.11.2138