Regulation of Immune Responses by Nonhematopoietic Cells in Asthma

Nonhematopoietic cells are emerging as important contributors to many inflammatory diseases, including allergic asthma. Recent advances have led to a deeper understanding of how these cells interact with traditional immune cells, thereby modulating their activities in both homeostasis and disease. I...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 206; no. 2; pp. 292 - 301
Main Authors Royer, Derek J, Cook, Donald N
Format Journal Article
LanguageEnglish
Published United States 15.01.2021
Subjects
Animals
Asthma - immunology
Cell Communication
Epithelial Cells - immunology
Fibroblasts - immunology
Humans
Immunity, Innate
Lung - immunology
Th2 Cells - immunology
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Summary:Nonhematopoietic cells are emerging as important contributors to many inflammatory diseases, including allergic asthma. Recent advances have led to a deeper understanding of how these cells interact with traditional immune cells, thereby modulating their activities in both homeostasis and disease. In addition to their well-established roles in gas exchange and barrier function, lung epithelial cells express an armament of innate sensors that can be triggered by various inhaled environmental agents, leading to the production of proinflammatory molecules. Advances in cell lineage tracing and single-cell RNA sequencing have expanded our knowledge of rare, but immunologically important nonhematopoietic cell populations. In parallel with these advances, novel reverse genetic approaches are revealing how individual genes in different lung-resident nonhematopoietic cell populations contribute to the initiation and maintenance of asthma. This knowledge is already revealing new pathways that can be selectively targeted to treat distinct forms of asthma.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.2000885