Rho GTPases and cell migration

Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the cellular responses required for cell migration. Recent research has revealed new molecular links between Rho family proteins and the actin cytoske...

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Bibliographic Details
Published inJournal of cell science Vol. 114; no. Pt 15; pp. 2713 - 2722
Main Author Ridley, A J
Format Journal Article
LanguageEnglish
Published England 01.08.2001
Subjects
Animals
Cell Adhesion - physiology
Cell Movement - physiology
Cytoskeleton - physiology
rho GTP-Binding Proteins - metabolism
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Summary:Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the cellular responses required for cell migration. Recent research has revealed new molecular links between Rho family proteins and the actin cytoskeleton, showing that they act to regulate actin polymerization, depolymerization and the activity of actin-associated myosins. In addition, studies on integrin signalling suggest that the substratum continuously feeds signals to Rho proteins in migrating cells to influence migration rate. There is also increasing evidence that Rho proteins affect the organization of the microtubule and intermediate filament networks and that this is important for cell migration.
Bibliography:ObjectType-Article-2
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ISSN:0021-9533
1477-9137
DOI:10.1242/jcs.114.15.2713