Two new glutarimide antibiotics from Streptomyces sp. HS-NF-780

Two new glutarimide antibiotics, 9-methylstreptimidone 2- α - d -glucopyranoside ( 1 ), and hydroxyiso-9-methylstreptimidone ( 2) , along with a known compound, 9-methylstreptimidone ( 3 ), have been isolated from the broth of Streptomyces sp. HS-NF-780. Their structures were determined on the basis...

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Bibliographic Details
Published inJournal of antibiotics Vol. 72; no. 4; pp. 241 - 245
Main Authors Zhao, Xue-Li, Wang, Han, Xue, Zheng-Lian, Li, Jian-Song, Qi, Huan, Zhang, Hui, Zhao, Tian, Wang, Ji-Dong, Xiang, Wen-Sheng
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.04.2019
Springer Nature
Nature Publishing Group
Subjects
631/154/309
631/67
Antibiotics
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Biotechnology & Applied Microbiology
Brief Communication
Immunology
Life Sciences
Life Sciences & Biomedicine
Medicinal Chemistry
Microbiology
Organic Chemistry
Pharmacology & Pharmacy
Science & Technology
ELUCIDATION
MIGRASTATIN
ANALOGS
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Summary:Two new glutarimide antibiotics, 9-methylstreptimidone 2- α - d -glucopyranoside ( 1 ), and hydroxyiso-9-methylstreptimidone ( 2) , along with a known compound, 9-methylstreptimidone ( 3 ), have been isolated from the broth of Streptomyces sp. HS-NF-780. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. By modified Mosher’s method and acid hydrolysis, the absolute configurations of compounds 1 and 2 were established. Compounds 1 and 2 exhibited moderate cytotoxic activity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-019-0143-6