Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399

• Published in: Journal of antibiotics Vol. 72; no. 1; pp. 45 - 49
• Main Authors: Cong, Ziwen, Huang, Xiaolong, Liu, Yunhao, Liu, Yuxuan, Wang, Pei, Liao, Shengrong, Yang, Bin, Zhou, Xuefeng, Huang, Dongyi, Wang, Junfeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2019; Japan Antibiotics Research Assoc; Nature Publishing Group
• Subjects: 631/154; 692/308/153; 692/699/255; Aminoglycosides - chemistry; Aminoglycosides - isolation & purification; Aminoglycosides - pharmacology; Anthracyclines - chemistry; Anthracyclines - isolation & purification; Anthracyclines - pharmacology; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Aquatic Organisms - chemistry; Aquatic Organisms - isolation & purification; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Brief Communication; Cell Survival - drug effects; Cytotoxicity; Humans; Immunology; Inhibitory Concentration 50; K562 Cells - drug effects; K562 Cells - physiology; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Microbial Sensitivity Tests; Microbiology; Molecular Structure; Organic Chemistry; Pharmacology & Pharmacy; Science & Technology; Spectrum Analysis; Streptococcus agalactiae - drug effects; Streptomyces - chemistry; Streptomyces - isolation & purification; ALKALOIDS

Aranciamycin K ( 1 ) and isotirandamycin B ( 2 ) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives ( 3 – 6 ), and two known tirandamycin derivatives ( 7 and 8 ). Their structures including absolute configurations were...