Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399

• Published in: Journal of antibiotics Vol. 72; no. 1; pp. 45 - 49
• Main Authors: Cong, Ziwen, Huang, Xiaolong, Liu, Yunhao, Liu, Yuxuan, Wang, Pei, Liao, Shengrong, Yang, Bin, Zhou, Xuefeng, Huang, Dongyi, Wang, Junfeng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2019; Japan Antibiotics Research Assoc; Nature Publishing Group
• Subjects: 631/154; 692/308/153; 692/699/255; Aminoglycosides - chemistry; Aminoglycosides - isolation & purification; Aminoglycosides - pharmacology; Anthracyclines - chemistry; Anthracyclines - isolation & purification; Anthracyclines - pharmacology; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Aquatic Organisms - chemistry; Aquatic Organisms - isolation & purification; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Brief Communication; Cell Survival - drug effects; Cytotoxicity; Humans; Immunology; Inhibitory Concentration 50; K562 Cells - drug effects; K562 Cells - physiology; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Microbial Sensitivity Tests; Microbiology; Molecular Structure; Organic Chemistry; Pharmacology & Pharmacy; Science & Technology; Spectrum Analysis; Streptococcus agalactiae - drug effects; Streptomyces - chemistry; Streptomyces - isolation & purification; ALKALOIDS
• ISSN: 0021-8820; 1881-1469; 1881-1469
• DOI: 10.1038/s41429-018-0103-6

Aranciamycin K ( 1 ) and isotirandamycin B ( 2 ) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives ( 3 – 6 ), and two known tirandamycin derivatives ( 7 and 8 ). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2 , 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 μM, respectively. Besides, compounds 3 , 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC 50 values of 22.0 ± 0.20, 1.80 ± 0.01 and 12.1 ± 0.07 μM, respectively.