Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399
Aranciamycin K ( 1 ) and isotirandamycin B ( 2 ) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives ( 3 – 6 ), and two known tirandamycin derivatives ( 7 and 8 ). Their structures including absolute configurations were...
Saved in:
| Published in | Journal of antibiotics Vol. 72; no. 1; pp. 45 - 49 |
|---|---|
| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.01.2019
Japan Antibiotics Research Assoc Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Aranciamycin K (
1
) and isotirandamycin B (
2
) were isolated from a marine-derived
Streptomyces
sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (
3
–
6
), and two known tirandamycin derivatives (
7
and
8
). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds
2
,
7
and
8
displayed potent bacteriostatic effects against
Streptococcus agalactiae
with MIC values of 11.5, 5.9 and 5.7 μM, respectively. Besides, compounds
3
,
5
and
6
exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC
50
values of 22.0 ± 0.20, 1.80 ± 0.01 and 12.1 ± 0.07 μM, respectively. |
|---|---|
| AbstractList | Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 mu M, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC(50 )values of 22.0 +/- 0.20, 1.80 +/- 0.01 and 12.1 +/- 0.07 mu M, respectively. Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 μM, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC50 values of 22.0 ± 0.20, 1.80 ± 0.01 and 12.1 ± 0.07 μM, respectively.Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 μM, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC50 values of 22.0 ± 0.20, 1.80 ± 0.01 and 12.1 ± 0.07 μM, respectively. Aranciamycin K ( 1 ) and isotirandamycin B ( 2 ) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives ( 3 – 6 ), and two known tirandamycin derivatives ( 7 and 8 ). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2 , 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 μM, respectively. Besides, compounds 3 , 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC 50 values of 22.0 ± 0.20, 1.80 ± 0.01 and 12.1 ± 0.07 μM, respectively. Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3–6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 μM, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC50 values of 22.0 ± 0.20, 1.80 ± 0.01 and 12.1 ± 0.07 μM, respectively. Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 μM, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC values of 22.0 ± 0.20, 1.80 ± 0.01 and 12.1 ± 0.07 μM, respectively. |
| Author | Zhou, Xuefeng Huang, Xiaolong Wang, Junfeng Huang, Dongyi Liu, Yunhao Liao, Shengrong Yang, Bin Liu, Yuxuan Wang, Pei Cong, Ziwen |
| Author_xml | – sequence: 1 givenname: Ziwen surname: Cong fullname: Cong, Ziwen organization: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Institute of Tropical Agriculture and Forestry, Hainan University – sequence: 2 givenname: Xiaolong surname: Huang fullname: Huang, Xiaolong email: hxl2012@163.com organization: Institute of Tropical Agriculture and Forestry, Hainan University – sequence: 3 givenname: Yunhao surname: Liu fullname: Liu, Yunhao organization: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences – sequence: 4 givenname: Yuxuan surname: Liu fullname: Liu, Yuxuan organization: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences – sequence: 5 givenname: Pei surname: Wang fullname: Wang, Pei organization: Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences – sequence: 6 givenname: Shengrong surname: Liao fullname: Liao, Shengrong organization: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences – sequence: 7 givenname: Bin surname: Yang fullname: Yang, Bin organization: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences – sequence: 8 givenname: Xuefeng orcidid: 0000-0001-9601-4869 surname: Zhou fullname: Zhou, Xuefeng organization: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences – sequence: 9 givenname: Dongyi surname: Huang fullname: Huang, Dongyi organization: Institute of Tropical Agriculture and Forestry, Hainan University – sequence: 10 givenname: Junfeng orcidid: 0000-0001-6702-5366 surname: Wang fullname: Wang, Junfeng email: wangjunfeng@scsio.ac.cn, jfwang2012@163.com organization: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30258222$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkkFvFCEUgImpsdvqD_BiJvFiYqbyYJiBo5lYbdKkh9UzYYCpNDOwAlvdf18ms9WkicYDAR7f9-CRd4ZOfPAWodeALwBT_iE10BBRY-BlYFq3z9AGOIcamlacoA3GBGrOCT5FZyndYUw72vEX6JRiwjghZINSf8ghh19OV8rn71Hpg56ct2VnlogblM42OjVV2cUSVPNBO1-O1BRu9zZVYwxzpapZxaLVprD31lTbHO0uhwIXJO0uqm2_vbqpGqBCvETPRzUl--o4n6Nvl5--9l_q65vPV_3H61pT0eZaKQbdCA0IsHYwgxWWCaCcKWUazXGnuGGWGRAdsI6IDmND8WjAdKxhStBz9G7Nu4vhR3lqlrNL2k6T8jbskyQAlLQdpaygb5-gd2EfS40LxRgWbQukUG-O1H6YrZG76ErZB_n4nQXgK_DTDmFM2lmv7W8MY9yUXFTQssJt77LKLvg-7H0u6vv_VwvdrbSOIaVoR6mP2XJUbpKA5dIhcu0QWTpELh0iFxOemI93_Mshq5MK629t_PM7f5ceAK9lycY |
| CitedBy_id | crossref_primary_10_1007_s11356_021_16104_6 crossref_primary_10_3390_microorganisms10071349 crossref_primary_10_1021_acs_jnatprod_1c00297 crossref_primary_10_3390_md18120645 crossref_primary_10_2174_1568026619666191114102359 crossref_primary_10_3390_md22010051 crossref_primary_10_3390_md18020114 crossref_primary_10_1039_D0NP00089B crossref_primary_10_3390_md20010006 crossref_primary_10_1039_D1NP00059D crossref_primary_10_1038_s41598_023_32043_3 crossref_primary_10_3390_md19110629 crossref_primary_10_3390_agronomy9030121 crossref_primary_10_1007_s12272_020_01251_0 crossref_primary_10_1039_D1NP00067E crossref_primary_10_1007_s00210_025_04001_5 crossref_primary_10_54393_fbt_v4i04_146 crossref_primary_10_3390_molecules28155915 crossref_primary_10_3390_microorganisms11102444 crossref_primary_10_1007_s12223_024_01209_5 crossref_primary_10_1007_s44307_024_00034_8 crossref_primary_10_3390_antibiotics11070965 |
| Cites_doi | 10.1039/b600666n 10.1038/nchem.1087 10.1016/j.steroids.2017.12.001 10.1021/np9005597 10.1080/07328308908048008 10.7164/antibiotics.50.522 10.1016/j.fitote.2017.01.005 10.1021/ol503646c 10.1021/ol200447h 10.1021/acs.orglett.7b02758 10.1021/cr00038a009 10.1021/acs.jafc.6b00527 10.1007/128_2008_5 10.1038/NCHEM.1087 |
| ContentType | Journal Article |
| Copyright | The Author(s) under exclusive licence to the Japan Antibiotics Research Association 2018 Copyright Nature Publishing Group Jan 2019 |
| Copyright_xml | – notice: The Author(s) under exclusive licence to the Japan Antibiotics Research Association 2018 – notice: Copyright Nature Publishing Group Jan 2019 |
| DBID | AAYXX CITATION 17B 1KM AAWJD BLEPL DTL EGQ CGR CUY CVF ECM EIF NPM 3V. 7QL 7T5 7X7 7XB 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI Q9U 7X8 |
| DOI | 10.1038/s41429-018-0103-6 |
| DatabaseName | CrossRef Web of Knowledge Index Chemicus Web of Science - Science Citation Index Expanded - 2019 Web of Science Core Collection Science Citation Index Expanded Web of Science Primary (SCIE, SSCI & AHCI) Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Immunology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Central Korea ProQuest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | CrossRef Web of Science MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection Environmental Sciences and Pollution Management ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Web of Science MEDLINE - Academic ProQuest Central Student MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1881-1469 |
| EndPage | 49 |
| ExternalDocumentID | 30258222 000455039300006 10_1038_s41429_018_0103_6 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 41476135; 21502204 funderid: https://doi.org/10.13039/501100001809 – fundername: Pearl River S&T Nova Program of Guangzhou grantid: 201710010136 – fundername: National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) grantid: 41776169; 41476135; 21502204; 21772210; 81741154; 81741158 – fundername: High Education Teaching and reform Research Fund Program of Hainan province grantid: Hnjg2017ZD-3 – fundername: Science and Technology Project of Guangdong Province grantid: 2016A020222010 – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 21502204 – fundername: National Natural Science Foundation of China (National Science Foundation of China) grantid: 41476135 |
| GroupedDBID | --- -Q- -~X .55 .GJ 0R~ 29J 2WC 39C 3O- 3V. 4.4 406 41~ 53G 5GY 70F 7X7 88E 88I 8FI 8FJ AACDK AANZL AASML AATNV AAZLF ABAKF ABAWZ ABJNI ABUWG ABZZP ACAOD ACGFS ACKTT ACRQY ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AEUYN AEVLU AEXYK AFBBN AFKRA AFSHS AGAYW AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AXYYD AZQEC BAWUL BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU DIK DNIVK DPUIP DU5 DWQXO EBLON EBS EE. EIOEI EJD EMB EMOBN F5P FDQFY FERAY FIGPU FIZPM FSGXE FYUFA GNUQQ HCIFZ HMCUK HZ~ IWAJR JSF JSH JSO JZLTJ KQ8 M1P M2P M7P NAO NQJWS O9- OK1 P6G PKN PQQKQ PROAC PSQYO RJT RNT RNTTT ROL RZJ SNX SNYQT SOHCF SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TKC TR2 TSG UKHRP UPT W2D X7J X7M YQT ZGI ZXP AAYXX ABBRH ABDBE ABFSG ACSTC AEZWR AFDZB AFHIU AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT SOJ 17B 1KM ABRTQ BLEPL DTL GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED GROUPED_WOS_WEB_OF_SCIENCE CGR CUY CVF ECM EIF NPM 7QL 7T5 7XB 8FE 8FH 8FK C1K H94 K9. LK8 PJZUB PKEHL PPXIY PQEST PQGLB PQUKI Q9U 7X8 |
| ID | FETCH-LOGICAL-c396t-aa517f14191eebdbe9e591385aad4c807a8d5e5d19715729700d30fd1d7545a93 |
| IEDL.DBID | 7X7 |
| ISICitedReferencesCount | 21 |
| ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000455039300006 |
| ISSN | 0021-8820 1881-1469 |
| IngestDate | Mon Jul 21 11:36:23 EDT 2025 Sat Aug 23 13:31:36 EDT 2025 Thu Apr 03 07:06:46 EDT 2025 Wed Aug 06 04:58:29 EDT 2025 Fri Aug 29 16:14:40 EDT 2025 Thu Apr 24 23:10:06 EDT 2025 Tue Jul 01 01:56:17 EDT 2025 Fri Feb 21 02:37:12 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | ALKALOIDS |
| Language | English |
| LinkModel | DirectLink |
| LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
| MergedId | FETCHMERGED-LOGICAL-c396t-aa517f14191eebdbe9e591385aad4c807a8d5e5d19715729700d30fd1d7545a93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0001-9601-4869 0000-0001-6702-5366 |
| PMID | 30258222 |
| PQID | 2155096612 |
| PQPubID | 2041950 |
| PageCount | 5 |
| ParticipantIDs | webofscience_primary_000455039300006CitationCount crossref_citationtrail_10_1038_s41429_018_0103_6 crossref_primary_10_1038_s41429_018_0103_6 webofscience_primary_000455039300006 springer_journals_10_1038_s41429_018_0103_6 pubmed_primary_30258222 proquest_miscellaneous_2113267335 proquest_journals_2155096612 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-01-01 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: 2019-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: TOKYO – name: Japan – name: Tokyo |
| PublicationSubtitle | Official journal of the Society for Actinomycetes, Japan |
| PublicationTitle | Journal of antibiotics |
| PublicationTitleAbbrev | J Antibiot J ANTIBIOT |
| PublicationTitleAlternate | J Antibiot (Tokyo) |
| PublicationYear | 2019 |
| Publisher | Nature Publishing Group UK Japan Antibiotics Research Assoc Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group UK – name: Japan Antibiotics Research Assoc – name: Nature Publishing Group |
| References | Royles (CR4) 1995; 95 Laatsch, Fotso (CR1) 2008; 282 Wang, Wei, Qin, Lin, Zhou, Liao (CR10) 2015; 17 Pang, Lin, Wang, Liang, Tian, Salendra (CR8) 2018; 129 Chen, Wang, Wang, Lin, Zhao, Kaliaperumal (CR9) 2017; 117 Johdo, Yoshioka (CR11) 1997; 50 Wang, He, Huang, Tian, Liao, Yang (CR13) 2016; 64 Gui, Mo, Gu, Ju (CR2) 2017; 19 Sann (CR3) 2006; 23 Carlson, Li, Burr, Sherman (CR6) 2009; 72 Carlson, Li, Gunatilleke, Anzai, Burr, Podust (CR7) 2011; 3 Mo, Huang, Ma, Wang, Wang, Zhang (CR5) 2011; 13 Hermentin, Raab, Paal, Boettger, Berscheid, Gerken (CR12) 1989; 8 JC Carlson (103_CR7) 2011; 3 H Laatsch (103_CR1) 2008; 282 XY Pang (103_CR8) 2018; 129 P Hermentin (103_CR12) 1989; 8 JC Carlson (103_CR6) 2009; 72 BJL Royles (103_CR4) 1995; 95 ST Chen (103_CR9) 2017; 117 CL Sann (103_CR3) 2006; 23 JF Wang (103_CR10) 2015; 17 JF Wang (103_CR13) 2016; 64 XH Mo (103_CR5) 2011; 13 C Gui (103_CR2) 2017; 19 O Johdo (103_CR11) 1997; 50 Wang, JF (WOS:000374275100013) 2016; 64 Wang, JF (WOS:000349274200067) 2015; 17 Carlson, JC (WOS:000292999100016) 2011; 3 Gui, C (WOS:000413709600031) 2017; 19 Laatsch, H (WOS:000258827500001) 2008; 282 Carlson, JC (WOS:000272227600034) 2009; 72 SANN CL (WOS:000455039300006.11) 2006; 23 Pang, XY (WOS:000423006000006) 2018; 129 HERMENTIN, P (WOS:A1989U447900006) 1989; 8 Mo, XH (WOS:000289956700018) 2011; 13 ROYLES, BJL (WOS:A1995RY99500010) 1995; 95 Chen, ST (WOS:000395852600013) 2017; 117 Johdo, O (WOS:A1997XG46000011) 1997; 50 |
| References_xml | – volume: 23 start-page: 357 year: 2006 end-page: 67 ident: CR3 article-title: Maleimide spacers as versatile linkers in the synthesis of bioconjugates of anthracyclines publication-title: Nat Prod Rep doi: 10.1039/b600666n – volume: 3 start-page: 628 year: 2011 end-page: 33 ident: CR7 article-title: Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes publication-title: Nat Chem doi: 10.1038/nchem.1087 – volume: 129 start-page: 41 year: 2018 end-page: 6 ident: CR8 article-title: Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus sp. SCSIO41007 publication-title: Steroids doi: 10.1016/j.steroids.2017.12.001 – volume: 72 start-page: 2076 year: 2009 end-page: 9 ident: CR6 article-title: Isolation and characterization of tirandamycins from a marine-derived sp publication-title: J Nat Prod doi: 10.1021/np9005597 – volume: 8 start-page: 255 year: 1989 end-page: 63 ident: CR12 article-title: Synthesis and structure elucidation of -methoxybenzoyl derivatives of rhodomycins publication-title: J Carbohyd Chem doi: 10.1080/07328308908048008 – volume: 50 start-page: 522 year: 1997 end-page: 5 ident: CR11 article-title: Isolation of new anthracyclines 10- -rhodosaminyl β-rhodomycinone and β-isorhodomycinone from mild-acid treated culture of obelmycin-producing publication-title: J Antibiot doi: 10.7164/antibiotics.50.522 – volume: 117 start-page: 71 year: 2017 end-page: 8 ident: CR9 article-title: Structurally diverse secondary metabolites from a deep-sea-derived fungus SCSIO 41001 and their biological evaluation publication-title: Fitoterapia doi: 10.1016/j.fitote.2017.01.005 – volume: 17 start-page: 656 year: 2015 end-page: 9 ident: CR10 article-title: Arthpyrones A–C, pyridone alkaloids from a sponge-derived fungus ZSDS1-F3 publication-title: Org Lett doi: 10.1021/ol503646c – volume: 13 start-page: 2212 year: 2011 end-page: 5 ident: CR5 article-title: Characterization of as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway publication-title: Org Lett doi: 10.1021/ol200447h – volume: 19 start-page: 5617 year: 2017 end-page: 20 ident: CR2 article-title: Elucidating the sugar tailoring steps in the cytorhodin biosynthetic pathway publication-title: Org Lett doi: 10.1021/acs.orglett.7b02758 – volume: 95 start-page: 1981 year: 1995 end-page: 2001 ident: CR4 article-title: Naturally occurring tetramic acids: structure, isolation, and synthesis publication-title: Chem Rev doi: 10.1021/cr00038a009 – volume: 64 start-page: 2910 year: 2016 end-page: 6 ident: CR13 article-title: Antifungal new oxepine-containing alkaloids and xanthones from the deep-sea-derived fungus SCSIO 05879 publication-title: J Agric Food Chem doi: 10.1021/acs.jafc.6b00527 – volume: 282 start-page: 3 year: 2008 end-page: 74 ident: CR1 article-title: Naturally occurring anthracyclines publication-title: Top Curr Chem doi: 10.1007/128_2008_5 – volume: 129 start-page: 41 year: 2018 ident: 103_CR8 publication-title: Steroids doi: 10.1016/j.steroids.2017.12.001 – volume: 19 start-page: 5617 year: 2017 ident: 103_CR2 publication-title: Org Lett doi: 10.1021/acs.orglett.7b02758 – volume: 117 start-page: 71 year: 2017 ident: 103_CR9 publication-title: Fitoterapia doi: 10.1016/j.fitote.2017.01.005 – volume: 13 start-page: 2212 year: 2011 ident: 103_CR5 publication-title: Org Lett doi: 10.1021/ol200447h – volume: 72 start-page: 2076 year: 2009 ident: 103_CR6 publication-title: J Nat Prod doi: 10.1021/np9005597 – volume: 64 start-page: 2910 year: 2016 ident: 103_CR13 publication-title: J Agric Food Chem doi: 10.1021/acs.jafc.6b00527 – volume: 23 start-page: 357 year: 2006 ident: 103_CR3 publication-title: Nat Prod Rep doi: 10.1039/b600666n – volume: 3 start-page: 628 year: 2011 ident: 103_CR7 publication-title: Nat Chem doi: 10.1038/nchem.1087 – volume: 17 start-page: 656 year: 2015 ident: 103_CR10 publication-title: Org Lett doi: 10.1021/ol503646c – volume: 282 start-page: 3 year: 2008 ident: 103_CR1 publication-title: Top Curr Chem doi: 10.1007/128_2008_5 – volume: 50 start-page: 522 year: 1997 ident: 103_CR11 publication-title: J Antibiot doi: 10.7164/antibiotics.50.522 – volume: 8 start-page: 255 year: 1989 ident: 103_CR12 publication-title: J Carbohyd Chem doi: 10.1080/07328308908048008 – volume: 95 start-page: 1981 year: 1995 ident: 103_CR4 publication-title: Chem Rev doi: 10.1021/cr00038a009 – volume: 17 start-page: 656 year: 2015 ident: WOS:000349274200067 article-title: Arthpyrones A-C, Pyridone Alkaloids from a Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3 publication-title: ORGANIC LETTERS doi: 10.1021/ol503646c – volume: 64 start-page: 2910 year: 2016 ident: WOS:000374275100013 article-title: Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879 publication-title: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY doi: 10.1021/acs.jafc.6b00527 – volume: 72 start-page: 2076 year: 2009 ident: WOS:000272227600034 article-title: Isolation and Characterization of Tirandamycins from a Marine-Derived Streptomyces sp. publication-title: JOURNAL OF NATURAL PRODUCTS doi: 10.1021/np9005597 – volume: 95 start-page: 1981 year: 1995 ident: WOS:A1995RY99500010 article-title: NATURALLY-OCCURRING TETRAMIC ACIDS - STRUCTURE, ISOLATION, AND SYNTHESIS publication-title: CHEMICAL REVIEWS – volume: 50 start-page: 522 year: 1997 ident: WOS:A1997XG46000011 article-title: Isolation of new anthracyclines 10-O-rhodosaminyl beta-rhodomycinone and beta-isorhodomycinone from mild-acid treated culture of obelmycin-producing Streptomyces violaceus publication-title: JOURNAL OF ANTIBIOTICS – volume: 8 start-page: 255 year: 1989 ident: WOS:A1989U447900006 article-title: SYNTHESIS AND STRUCTURE ELUCIDATION OF PARA-METHOXYBENZOYL DERIVATIVES OF RHODOMYCINS publication-title: JOURNAL OF CARBOHYDRATE CHEMISTRY – volume: 3 start-page: 628 year: 2011 ident: WOS:000292999100016 article-title: Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes publication-title: NATURE CHEMISTRY doi: 10.1038/NCHEM.1087 – volume: 129 start-page: 41 year: 2018 ident: WOS:000423006000006 article-title: Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp SCSIO41007 publication-title: STEROIDS doi: 10.1016/j.steroids.2017.12.001 – volume: 19 start-page: 5617 year: 2017 ident: WOS:000413709600031 article-title: Elucidating the Sugar Tailoring Steps in the Cytorhodin Biosynthetic Pathway publication-title: ORGANIC LETTERS doi: 10.1021/acs.orglett.7b02758 – volume: 282 start-page: 3 year: 2008 ident: WOS:000258827500001 article-title: Naturally occurring anthracyclines publication-title: ANTHRACYCLINE CHEMISTRY AND BIOLOGY I: BIOLOGICAL OCCURENCE AND BIOSYNTHESIS, SYNTHESIS AND CHEMISTRY doi: 10.1007/128_2008_5 – volume: 13 start-page: 2212 year: 2011 ident: WOS:000289956700018 article-title: Characterization of TrdL as a 10-Hydroxy Dehydrogenase and Generation of New Analogues from a Tirandamycin Biosynthetic Pathway publication-title: ORGANIC LETTERS doi: 10.1021/ol200447h – volume: 23 start-page: 357 year: 2006 ident: WOS:000455039300006.11 publication-title: NAT PROD REP – volume: 117 start-page: 71 year: 2017 ident: WOS:000395852600013 article-title: Structurally diverse secondary metabolites from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001 and their biological evaluation publication-title: FITOTERAPIA doi: 10.1016/j.fitote.2017.01.005 |
| SSID | ssj0037378 |
| Score | 2.3259842 |
| Snippet | Aranciamycin K (
1
) and isotirandamycin B (
2
) were isolated from a marine-derived
Streptomyces
sp. SCSIO 41399, along with the previously reported four... Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four... |
| Source | Web of Science |
| SourceID | proquest pubmed webofscience crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 45 |
| SubjectTerms | 631/154 692/308/153 692/699/255 Aminoglycosides - chemistry Aminoglycosides - isolation & purification Aminoglycosides - pharmacology Anthracyclines - chemistry Anthracyclines - isolation & purification Anthracyclines - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Aquatic Organisms - chemistry Aquatic Organisms - isolation & purification Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Biotechnology & Applied Microbiology Brief Communication Cell Survival - drug effects Cytotoxicity Humans Immunology Inhibitory Concentration 50 K562 Cells - drug effects K562 Cells - physiology Life Sciences Life Sciences & Biomedicine Medicinal Chemistry Microbial Sensitivity Tests Microbiology Molecular Structure Organic Chemistry Pharmacology & Pharmacy Science & Technology Spectrum Analysis Streptococcus agalactiae - drug effects Streptomyces - chemistry Streptomyces - isolation & purification |
| Title | Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399 |
| URI | https://link.springer.com/article/10.1038/s41429-018-0103-6 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000455039300006 https://www.ncbi.nlm.nih.gov/pubmed/30258222 https://www.proquest.com/docview/2155096612 https://www.proquest.com/docview/2113267335 |
| Volume | 72 |
| WOS | 000455039300006 |
| WOSCitedRecordID | wos000455039300006 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9RAEF-0ffFF_DZaywqlD9rYbDb79SS9o0cRPA5t4d7CZncPDtrkbFLx_ntnklyuohw-hSSTz5md_c3MzgwhR8Y7yb0r4pDaFAwUqWPtFyDLIaQFc1omGSYKf53Ki6vsy1zMe4db3S-r3OjEVlH7yqGP_DRFLA3YnKWfVz9i7BqF0dW-hcZDso-ly3BJl5oPBhdXvNfEKYsBSQ5RTa5P64yBJgZDGpdyJTyWf85Lf4HNe4HSf05R7XQ0eUIe9ziSnnWMf0oehPIZOZ51hajXJ_Rym1dVn9BjOtuWqF4_J_V43VRN9WvpqMVOCXAJpkgG2PN4ZFl0RZzhCc3yFp0NN2u3LOFU5-upKaalUEtvLGYPxh5ofwZPMca9aiogBpJ69Yl-H4OypjCFGfOCXE3OL8cXcd9-IXbcyCa2VjC1YBlYdCEUvggmCMO4Ftb6zOlEWe1FEJ4ZxQRgdJUknicLz7wCWGYNf0n2yqoMrwkVPlMLGQoBPMyMzwrtwkJoKVXqmMnSiCSbn5-7vjY5tsi4ztsYOdd5x68c-JUjv3IZkQ_DJauuMMcu4oMNR_N-jNb5VqIi8n44DaMLQya2DNUd0oC1LhXnIiKvOkkYnsYBLiK8isjHjWhsb77jVY7uS89wtxZcC8yUbiFERNj_kI37n4UFDJo3u7_yLXkEaM90_qMDstfc3oV3gKia4rAdNodk_2wyGk1hOzqfzr79BnzmHRY |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEB5V6QEuiDemBRap9AB16_V6_TggBKFVStsoglTqzax3N1Ikaqe1C-RP8RuZ8SMpAkVcerQ9u37M7Mw3O54ZgK3E6FAYnbnWVz46KGHsxmaCsmytn3Edh15AicInw3BwGnw6k2dr8KvLhaHfKjudWCtqU2jaI9_zCUsjNuf-u9mFS12jKLratdBoxOLIzn-gy1a-PfyI_H3l-wf74_7AbbsKuFokYeUqJXk04QE6KtZmJrOJlQkXsVTKBDr2IhUbaaXhScQlQs_I84zwJoabCNGGouJLqPLXA4GuTA_WP-wPR5873S8i0ep-n7uIXRdxVBHvlQFH3Y-uO_085gk3_NMS_gVvr4Vm_2kUawN4cBfutMiVvW9E7R6s2fw-bI-a0tfzHTZeZnKVO2ybjZZFsecPoOzPq6Iqfk41U9SbAYdQUqbFI0NnpllTNhrvUE0vaXvjfK6nOV5qdpdKRokwTLFzRfmKrkHa79YwiqrPqgKJkaSc7bIvfTQPDI1mkjyE0xthzSPo5UVunwCTJogmoc0kSk2QmCCLtZ3IOAwjX_Mk8B3wuo-f6rYaOjXl-JbWUXkRpw2_UuRXSvxKQwdeL4bMmlIgq4g3O46mrVYo06UMO_BycRnXMwVpVG6LK6LhiKgjIaQDjxtJWNxNIEAlQOfAm040lpOveJSt69KzmK2G85Jys2vQ4gD_H7J--7GoZEL1dPVbvoBbg_HJcXp8ODzagNuINZNm92oTetXllX2GeK7KnreLiMHXm163vwHaQFe7 |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqIiEuiDehBYxUeoCGjeM4dg4IoS2rlkK1Eq20t-DYjrRSmyxNCuxf49cxk9cWgVZcekwyeXlmPN94PDOE7CTWxNyazHehDsFBiZWvbA6y7FyYMaPiIMJE4c_H8cFp9HEmZhvkV58Lg9sq-zmxmahtaXCNfBQilgZszsJR3m2LmO5P3i2--dhBCiOtfTuNVkSO3PIHuG_V28N94PXLMJx8OBkf-F2HAd_wJK59rQWTOYvAaXEus5lLnEgYV0JrGxkVSK2scMKyRDIBMFQGgeVBbpmVgDw0FmKC6f-G5IKhjsnZ4OxxyTsrEDIfUOwQUeVqVEUMrAA48biNLOB-_KdN_AvoXgnS_tM8NqZwcofc7jAsfd8K3V2y4Yp7ZHfaFsFe7tGTVU5XtUd36XRVHnt5n1TjZV3W5c-5oRq7NMAtmJ7p4MjimXnWFpCGN9TzC1zoOF-aeQGX2nWmimJKDNX0XGPmom-B9ruzFOPri7oEYiCpFm_olzEYCgrmM0kekNNrYcxDslmUhXtMqLCRzGOXCZCfKLFRpozLhYpjGRqWRKFHgn7wU9PVRcf2HGdpE5_nKm35lQK_UuRXGnvk1XDLoi0Kso54u-do2s0PVbqSZo-8GC6DZmO4RheuvEQaBthaci488qiVhOFtHKAqQjuPvO5FY_XwNZ-yc1V6hqc1wF5glnYDXzzC_ods3A0WFk-on6z_y-fkJmhr-unw-GiL3ALQmbTLWNtks764dE8B2NXZs0aDKPl63Sr7G0q9Wos |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cytotoxic+anthracycline+and+antibacterial+tirandamycin+analogues+from+a+marine-derived+Streptomyces+sp.+SCSIO+41399&rft.jtitle=Journal+of+antibiotics&rft.au=Cong%2C+Ziwen&rft.au=Huang%2C+Xiaolong&rft.au=Liu%2C+Yunhao&rft.au=Liu%2C+Yuxuan&rft.date=2019-01-01&rft.issn=0021-8820&rft.eissn=1881-1469&rft.volume=72&rft.issue=1&rft.spage=45&rft.epage=49&rft_id=info:doi/10.1038%2Fs41429-018-0103-6&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41429_018_0103_6 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-8820&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-8820&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-8820&client=summon |