PML nuclear bodies, membrane-less domains acting as ROS sensors?

PML Nuclear bodies (PML NBs) are spherical domains associated with a broad range of activities upon stress responses such as apoptosis, senescence DNA repair, epigenetic control, as well as control of oncogenesis. These bodies are considered as privileged sites for post-translational modifications,...

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Published inSeminars in cell & developmental biology Vol. 80; pp. 29 - 34
Main Authors Niwa-Kawakita, Michiko, Wu, Hsin-Chieh, Thé, Hugues de, Lallemand-Breitenbach, Valérie
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2018
Elsevier
Subjects
Animals
Cell Nucleus - metabolism
Humans
Intranuclear Inclusion Bodies - metabolism
Life Sciences
NRF2
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Oxidative stress
Oxidative Stress - physiology
P53
PML nuclear bodies
Reactive Oxygen Species - metabolism
Sumoylation
Transcription Factors - metabolism
Oxidative stress
TRIM
KEAP1
OXPHOS
PML nuclear bodies
RNF4
HIF1A
FOXO1
NRF2
PPAR
mTOR
AML
SUMO
AKT
PML
RA
P53
FAO
ROS
RARA
Sumoylation
AMPK
APL
TP53
NBs
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Summary:PML Nuclear bodies (PML NBs) are spherical domains associated with a broad range of activities upon stress responses such as apoptosis, senescence DNA repair, epigenetic control, as well as control of oncogenesis. These bodies are considered as privileged sites for post-translational modifications, where sumoylation plays a key role. Here we summarize recent in vitro and in vivo findings on the link between PML NBs and ROS, in particular PML contributions to oxidative stress response. We discuss how it may regulate switch from cell protection against stress to cell arrest/cell death.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2017.11.007