Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene

We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK97-94. We identified the biosynthetic gene cluster for 1233A, an HMG-CoA synthase inhibit...

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Published inJournal of antibiotics Vol. 73; no. 7; pp. 475 - 479
Main Authors Kato, Sho, Motoyama, Takayuki, Uramoto, Masakazu, Nogawa, Toshihiko, Kamakura, Takashi, Osada, Hiroyuki
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2020
Nature Publishing Group
Subjects
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631/326/2522
631/92/349
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Brief Communication
Fatty Acids, Unsaturated - genetics
Fungi - genetics
Fungi - metabolism
Furans - metabolism
Fusarium - genetics
Fusarium - metabolism
Hydroxymethylglutaryl-CoA Synthase - antagonists & inhibitors
Hygromycin B - metabolism
Lactones
Life Sciences
Medicinal Chemistry
Metabolites
Microbiology
Multigene Family - genetics
Naphthoquinones - metabolism
Organic Chemistry
Protein synthesis
Pyrroles - metabolism
Secondary metabolites
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Summary:We found that the protein synthesis inhibitor hygromycin B induced the production of secondary metabolites, including lucilactaene, NG-391, fusarubin, 1233A, and 1233B, in the filamentous fungus, Fusarium sp. RK97-94. We identified the biosynthetic gene cluster for 1233A, an HMG-CoA synthase inhibitor. The biosynthetic gene cluster consisted of four genes, one of which was involved in conferring self-resistance to 1233A.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-020-0295-4