Antibacterial diketopiperazines from an endophytic fungus Bionectria sp. Y1085
Two new diketopiperazines ( 1 , 2 ), one new polyprenol ( 3 ), together with 19 known compounds ( 4 – 22 ) were obtained from the EtOAc extract of Bionectria sp. Y1085, an endophytic fungus isolated from the plant Huperzia serrata . Their structures were elucidated by extensive NMR and MS analysis....
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| Published in | Journal of antibiotics Vol. 72; no. 10; pp. 752 - 758 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.10.2019
Springer Nature Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Summary: | Two new diketopiperazines (
1
,
2
), one new polyprenol (
3
), together with 19 known compounds (
4
–
22
) were obtained from the EtOAc extract of
Bionectria
sp. Y1085, an endophytic fungus isolated from the plant
Huperzia serrata
. Their structures were elucidated by extensive NMR and MS analysis. Bionectin D (
1
) is a rare diketopiperazine with a single methylthio substitution at the
α
-carbon of cyclized amino acid residue. The antibacterial activity of compounds was assayed against
Escherichia coli
,
Staphylococcus aureus
, and
Salmonella typhimurium
ATCC 6539, and some metabolites (
1
,
2
,
10
,
11
, and
14
) exhibited evident antibacterial activity. |
|---|---|
| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0021-8820 1881-1469 |
| DOI: | 10.1038/s41429-019-0209-5 |