Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation

NOD1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-derived fragments and induce pro-inflammatory responses. Recent work provides evidence for a role for NOD1/NOD2 signaling in mediating ER-stress-induced inflammatory responses via a peptidoglycan-...

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Published inCurrent biology Vol. 26; no. 12; pp. R508 - R511
Main Authors Caruso, Roberta, Núñez, Gabriel
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 20.06.2016
Subjects
Brucella abortus
Endoplasmic Reticulum Stress
Immunity, Innate
Inflammation - metabolism
Nod1 Signaling Adaptor Protein - metabolism
Nod2 Signaling Adaptor Protein - metabolism
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Summary:NOD1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-derived fragments and induce pro-inflammatory responses. Recent work provides evidence for a role for NOD1/NOD2 signaling in mediating ER-stress-induced inflammatory responses via a peptidoglycan-independent mechanism. NOD1 and NOD2, two members of the intracellular NOD-like receptor family, sense bacterial peptidoglycan-derived fragments and induce pro-inflammatory responses. Recent work provides evidence for a role for NOD1/NOD2 signaling in mediating ER-stress-induced inflammatory responses via a peptidoglycan-independent mechanism.
Bibliography:ObjectType-Article-2
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ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2016.05.021