Comparative Whole Metagenome Analysis in Lesional and Nonlesional Scalp Areas of Patients with Psoriasis Capitis and Healthy Individuals

• Published in: Journal of investigative dermatology Vol. 145; no. 3; pp. 605 - 617.e14
• Main Authors: De Pessemier, Britta, López, Celia Díez, Taelman, Steff, Verdonck, Merel, Chen, Yang, Stockman, Annelies, Lambert, Jo, Van de Wiele, Tom, Callewaert, Chris
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2025
• Subjects: Adult; Case-Control Studies; Female; Humans; Male; Metagenome; Metagenomics; Microbiota - genetics; Middle Aged; Pathogenomics; Psoriasis - microbiology; Psoriasis - pathology; Psoriasis capitis; RNA, Ribosomal, 16S - genetics; Scalp - microbiology; Scalp - pathology; Scalp microbiome; Skin microbiome; Staphylococcus aureus - genetics; Staphylococcus aureus - isolation & purification; VF; Metagenomics; Pathogenomics; Scalp microbiome; AMP; FDR; AMR; rRNA; RND; Psoriasis capitis; Skin microbiome

Psoriasis is an immune-mediated inflammatory disorder, where the majority of the patients suffer from psoriasis capitis or scalp psoriasis. Current therapeutics remain ineffective to treat scalp lesions. In this study, we present a whole-metagenome characterization of the scalp microbiome in psorias...