Correlation of the Levels of microRNA with Cell Composition of Axillary Lymph Node in Wistar Rats with Breast Cancer

• Published in: Bulletin of experimental biology and medicine Vol. 168; no. 4; pp. 500 - 502
• Main Authors: Kabakov, A. V., Lykov, A. P., Kazakov, O. V., Poveshchenko, A. F., Poveshchenko, O. V., Kim, I. I., Bondarenko, N. A., Strunkin, D. N., Letyagin, A. Yu, Konenkov, V. I.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2020; Springer
• Subjects: Animals; Axilla; Biological products; Biomedical and Life Sciences; Biomedicine; Breast cancer; Cell Biology; Cell Count; Female; Gene Expression Regulation, Neoplastic; Internal Medicine; Laboratory Medicine; Lymph Nodes - immunology; Lymph Nodes - pathology; Lymphatic Metastasis; Lymphocytes - immunology; Lymphocytes - pathology; Macrophages - immunology; Macrophages - pathology; Mammary Glands, Animal - drug effects; Mammary Glands, Animal - immunology; Mammary Glands, Animal - pathology; Mammary Neoplasms, Experimental - chemically induced; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - immunology; Mammary Neoplasms, Experimental - pathology; Methylnitrosourea - administration & dosage; MicroRNA; MicroRNAs - genetics; MicroRNAs - immunology; Oncology; Pathology; Rats; Rats, Wistar; axillary lymph node; microRNA; breast cancer
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-020-04740-w

We studied the levels microRNA (miR-21, miR-221, miR-222, and miR-429) in blood serum, thoracic duct lymph, and breast cancer tissue, as well as the cell composition of the axillary lymph node in Wistar female rats with chemically induced breast cancer. The levels of miR-221 and miR-429 in the tumor tissue and in the lymph correlated with the decrease in lymphocyte number in the medullary cords of the axillary lymph nodes.