Identification of novel recombinants and proposed standard reference genomes for phylogenetic classification of canine parvovirus-2 (CPV-2): Comprehensive analysis revealing global evolutionary trait

Sustained spread and continuous evolution of CPV-2 generate new genetic information; nevertheless, there is no adopted phylogenetic tool, and parvo virologists still refer to the three antigenic variants. Herein, this report attempted to review the evolutionary trait of CPV-2 and proposed standard r...

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Published inFrontiers in veterinary science Vol. 9; p. 1030522
Main Authors Bahoussi, Amina Nawal, Wang, Pei-Hua, Ma, Zi-Hui, Rani, Nikita, Wu, Changxin, Xing, Li
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 15.11.2022
Subjects
canine parvovirus 2 (CPV-2)
genetic evolution
genotyping
parsimony-informative sites
recombination
Veterinary Science
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Summary:Sustained spread and continuous evolution of CPV-2 generate new genetic information; nevertheless, there is no adopted phylogenetic tool, and parvo virologists still refer to the three antigenic variants. Herein, this report attempted to review the evolutionary trait of CPV-2 and proposed standard reference genomes using the Maximum Likelihood-based phylogenetic analysis and Parsimony-Informative Sites. The analysis revealed three main evolutionary pathways where CPV-2 strains cluster into distinct clades depicted as GI, GII, or GIII, respectively. Furthermore, novel CPV-2 natural recombinants were detected, occurring only between the newly identified strains (2017–2020). Those findings provide unique insights into the evolutionary relatedness of CPV-2, clarify discrepancies between different geographic areas and will contribute to achieving a more reliable CPV-2 genetic and evolutionary genotyping classification.
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This article was submitted to Veterinary Infectious Diseases, a section of the journal Frontiers in Veterinary Science
Edited by: Min Yue, Zhejiang University, China
Reviewed by: Bharat Bhanderi, Kamdhenu University, India; Mithilesh Singh, Indian Veterinary Research Institute (IVRI), India; Israel Alejandro Quijano-Hernández, Universidad Autónoma del Estado de México, Mexico
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2022.1030522