Relative value of three whole-body MR approaches for PET-MR, including gadofosveset-enhanced MR, in comparison to PET-CT

Evaluate MR protocol for PET-MR including coronal DWI (cDWI), fat-suppressed T2 (T2w), and gadofosveset-enhanced T1 (CE). 18 patients underwent same-day PET-CT and PET-MR. Image quality and performance of each sequence, and combination of all three sequences, was evaluated with respect to PET-CT. Le...

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Published inClinical imaging Vol. 48; pp. 62 - 68
Main Authors Obara, Piotr, Loening, Andreas, Taviani, Valentina, Iagaru, Andrei, Hargreaves, Brian A., Vasanawala, Shreyas
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2018
Elsevier Limited
Subjects
Cancer
Computed tomography
Conspicuity
DWI
Image quality
Lesions
Medical imaging
Metastasis
NMR
Nuclear magnetic resonance
Pet-MR
Positron emission
Sensitivity
Studies
Tomography
Whole-body MRI
Whole-body MRI
DWI
Pet-MR
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Summary:Evaluate MR protocol for PET-MR including coronal DWI (cDWI), fat-suppressed T2 (T2w), and gadofosveset-enhanced T1 (CE). 18 patients underwent same-day PET-CT and PET-MR. Image quality and performance of each sequence, and combination of all three sequences, was evaluated with respect to PET-CT. Lesion conspicuity was best on cDWI, while delineation was best on CE. Considering all three sequences combined, both readers showed good sensitivity and specificity (>80%). Relative sensitivity was highest on CE and lowest on T2w. Whole-body MR performed well in detecting malignant lesions compared to PET-CT. CE showed overall highest performance. •MRI protocol proposed for whole-body PET-MRI, including coronal DWI, fat-suppressed T2, and gadofosveset-enhanced T1•MR sequences evaluated for image quality and performance compared to PET-CT•Whole-body MR performed well in detecting malignant lesion•Highest relative sensitivity was achieved with gadofosveset-enhanced T1 sequence
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2017.09.016