Intensive blood pressure control reduces the risk of progressive hemorrhage in patients with acute hypertensive intracerebral hemorrhage: A retrospective observational study

• Published in: Clinical neurology and neurosurgery Vol. 180; pp. 1 - 6
• Main Authors: Zhao, Jian-Lan, Du, Zhuo-Ying, Sun, Yi-Rui, Yuan, Qiang, Yu, Jian, Wu, Xing, Li, Zhi-Qi, Wu, Xue-Hai, Xie, Rong, Hu, Jin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2019; Elsevier Limited
• Subjects: Age; Blood pressure; Coma; Functional outcome; Gender; Hematoma; Hematoma expansion; Hemorrhage; Hypertension; Intensive blood pressure control; Intracerebral hemorrhage; Medical imaging; Mortality; Neurology; Observational studies; Patients; Stroke; Tomography; Hypertension; Intensive blood pressure control; Hematoma expansion; Intracerebral hemorrhage; Functional outcome
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2019.02.021

•We retrospectively investigated the effects of the new BP control protocols on acute hypertensive ICH patients.•Intensive BP control reduces the risk of progressive intracerebral hemorrhage.•Patients who received intensive BP control had favorable functional outcomes.•Intensive BP control is an independent factor in predicting hematoma growing. To investigate the impact of intensive blood pressure control on progressive intracerebral hemorrhage and outcome in patients with high blood pressure and intracerebral hemorrhage. A retrospective study was conducted recruiting 659 patients with acute hemorrhagic stroke between Jan. 2012 and May 2018. Patients recruited before May 2015 were treated with a target systolic level of <180 mm Hg, while those recruited after May 2015 received intensive blood pressure control treatment with a target systolic level of <140 mm Hg within 1 h. Uni- and multi-variate analysis were conducted to illustrate the association between intensive blood pressure control and progressive intracerebral hemorrhage. Mortality, rates of operation, length of ICU stay, modified Rankin scores at 90 days, and the rate of serious adverse events were also compared between the two groups. A total of 351 and 308 patients with acute hypertensive intracerebral hemorrhage were recruited before and after May 2015, respectively. Progressive intracerebral hemorrhage was identified among 111 out of 659 patients. Patients who received intensive blood pressure control showed a statistically lower rate of hematoma enlarging (43 of 308, 13.9% vs. 74 of 351, 21.1%, p = 0.018). The rates of operation and modified Rankin scores at 90 days were statistically lower with intensive blood control, while the mortality, length of ICU stay and rate of serious adverse events were similar between the two groups. Intensive BP control is an independent factor in predicting hematoma growing, with a more favorable discrimination (AUC = 0.889; 95%CI, 0.859–0.917) than other two models (AUC = 0.821; 95%CI, 0.791–0.852; and AUC = 0.635; 95%CI, 0.588–0.682). Intensive blood pressure control reduce the risk of progressive intracerebral hemorrhage and improved functional outcomes in patients with acute hemorrhagic stroke.