Clinical Use of Progestins and Their Mechanisms of Action: Present and Future (Review)

This review summarizes the current opinions on the mechanisms of action of nuclear, mitochondrial, and membrane progesterone receptors. The main aspects of the pharmacological action of progestins have been studied. Data on the clinical use of gestagens by nosological groups are presented. Particula...

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Published inSovremennye tekhnologii v medit͡s︡ine Vol. 13; no. 1; pp. 93 - 106
Main Author Fedotcheva, T A
Format Journal Article
LanguageEnglish
Published Russia (Federation) Privolzhsky Research Medical University 01.01.2021
Subjects
Medroxyprogesterone
Medroxyprogesterone Acetate - pharmacology
Megestrol
Progesterone
Progestins
Reviews
gestagens
megestrol acetate
medroxyprogesterone acetate
progesterone
progesterone receptors
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Summary:This review summarizes the current opinions on the mechanisms of action of nuclear, mitochondrial, and membrane progesterone receptors. The main aspects of the pharmacological action of progestins have been studied. Data on the clinical use of gestagens by nosological groups are presented. Particular attention is paid to progesterone, megestrol acetate, medroxyprogesterone acetate due to broadening of their spectrum of action. The possibilities of using gestagens as neuroprotectors, immunomodulators, and chemosensitizers are considered.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
How to cite: Fedotcheva T.A. Clinical use of progestins and their mechanisms of action: present and future (review). Sovremennye tehnologii v medicine 2021; 13(1): 93, https://doi.org/10.17691/stm2021.13.1.11
Conflict of interest. The authors have no conflict of interest to disclose.
ISSN:2076-4243
2309-995X
DOI:10.17691/stm2021.13.1.11