Phase I trials of antitumour agents: fundamental concepts

Phase I trials are an important step in the development of new drugs. Because of the advancing knowledge of cancer's molecular biology, these trials offer an important platform for the development of new agents and also for patient treatment. Therefore, comprehension of their peculiar terminolo...

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Bibliographic Details
Published inEcancermedicalscience Vol. 9; p. 501
Main Authors Toloi, Diego de Araujo, Jardim, Denis Leonardo Fontes, Hoff, Paulo Marcelo Gehm, Riechelmann, Rachel Simões Pimenta
Format Journal Article
LanguageEnglish
Published England Cancer Intelligence 19.01.2015
Subjects
Review
combination therapy
molecular-targeted drugs
phase I study
oncology
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Summary:Phase I trials are an important step in the development of new drugs. Because of the advancing knowledge of cancer's molecular biology, these trials offer an important platform for the development of new agents and also for patient treatment. Therefore, comprehension of their peculiar terminology and methodology are increasingly important. Our objectives were to review the fundamental concepts of phase I designs and to critically contextualise this type of study as a therapeutic option for patients with refractory cancer.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1754-6605
1754-6605
DOI:10.3332/ecancer.2015.501