Cytotoxic cassane diterpenoids from the seeds of Caesalpinia sappan

Phytochemical investigation on the seeds of Caesalpinia sappan led to the isolation of five new cassanetype diterpenoids, named 11-oxo-phanginin A（1）, caesalsappanins O–Q（2–4） and phanginin U（5）,together with five known compounds. The structures of the new compounds were elucidated by extensive anal...

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Published inChinese chemical letters Vol. 28; no. 8; pp. 1711 - 1715
Main Authors Wu, Zheng-Feng, Bao, Han, Zhou, Fa-Yang, Liu, Jing-Xin, Meng, Fan-Cheng, Feng, Lu, Lu, Jin-Jian, Zhang, Qing-Wen, Ye, Yang, Lin, Li-Gen
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.08.2017
Subjects
Caesalpinia sappan
Caesalsappanin
Cassane diterpenoid
Cytotoxicity
Phanginin
乳腺癌
二萜
化学成分
新化合物
核磁共振波谱数据
种子
细胞毒作用
苏木
Cytotoxicity
Caesalpinia sappan
Cassane diterpenoid
Phanginin
Caesalsappanin
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Summary:Phytochemical investigation on the seeds of Caesalpinia sappan led to the isolation of five new cassanetype diterpenoids, named 11-oxo-phanginin A（1）, caesalsappanins O–Q（2–4） and phanginin U（5）,together with five known compounds. The structures of the new compounds were elucidated by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the new compounds showed moderate cytotoxic effects on human breast cancer MCF-7 and human colon cancer HCT116 cell lines.
Bibliography:Phytochemical investigation on the seeds of Caesalpinia sappan led to the isolation of five new cassanetype diterpenoids, named 11-oxo-phanginin A（1）, caesalsappanins O–Q（2–4） and phanginin U（5）,together with five known compounds. The structures of the new compounds were elucidated by extensive analysis of mass spectrometric and 1D and 2D NMR spectroscopic data. All the new compounds showed moderate cytotoxic effects on human breast cancer MCF-7 and human colon cancer HCT116 cell lines.
11-2710/O6
Caesalpinia sappan Cassane diterpenoid Phanginin Caesalsappanin Cytotoxicity
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2017.04.023