Susceptibility of two strains of mice to the infection with Schistosoma mansoni: Parasitological and biochemical studies

• Published in: Parasitology research (1987) Vol. 103; no. 5; pp. 1059 - 1063
• Main Authors: Bin Dajem, Saad M, Mostafa, Osama M. S, El-Said, Fahmy G
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.10.2008; Springer-Verlag; Springer
• Subjects: Animals; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Genetic Predisposition to Disease; Immunology; Invertebrates; Male; Medical Microbiology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microbiology; Original Paper; Schistosoma mansoni - physiology; Schistosomiasis mansoni - genetics; Schistosomiasis mansoni - parasitology; Male Worm; Infected Mouse; Schistosomiasis; Schistosoma Mansoni; Intestinal Tissue; Infection; Schistosoma mansoni; Vertebrata; Mammalia; Sensitivity resistance; Mouse; Rodentia; Helmintha; Plathelmintha; Parasite; Invertebrata; Trematoda
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/s00436-008-1092-3

In this article, two strains of mice BALB/C and C57 were infected with Egyptian strain of Schistosoma mansoni. BALB/C mice appeared to harbor fewer parasites than did C57 mice. The hepatic and intestinal tissues of C57 mice were loaded with more eggs than that of BALB/C mice. Regardless the strain of mice, the number of eggs per gram of liver tissues was higher than in the intestinal tissues. Some biochemical parameters were measured in the liver of infected and non-infected mice; a significant decrease in the activities of alkaline phosphatase, catalase, glutathione-s-transferase, glutathione, and total lipids of infected mice compared to their matched control were observed. However, there was a significant increase in malondialdehyde level of infected mice compared to their matched group. Detailed discussion on the parasitological and biochemical differences between the two strains was presented.