NLRC5 Functions beyond MHC I Regulation-What Do We Know So Far?

NLRC5 is a member of the NLR family that acts as a transcriptional activator of MHC class I genes. In line with the function of several related NLR proteins in innate immune responses, there is, however, also ample evidence that NLRC5 contributes to innate and adaptive immune responses beyond the re...

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Published inFrontiers in immunology Vol. 8; p. 150
Main Authors Benkő, Szilvia, Kovács, Elek Gergő, Hezel, Felix, Kufer, Thomas A
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.02.2017
Subjects
Immunology
IFN
NF-κB
MHC
innate immunity
NLR
inflammasome
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Summary:NLRC5 is a member of the NLR family that acts as a transcriptional activator of MHC class I genes. In line with the function of several related NLR proteins in innate immune responses, there is, however, also ample evidence that NLRC5 contributes to innate and adaptive immune responses beyond the regulation of MHC class I genes. In human and murine cells, for example, NLRC5 was proposed to contribute to inflammatory and type I interferon responses. The role of NLRC5 in these and other cellular processes is hitherto still not well understood and blurred by discrepancies in the reported data. Here, we provide a detailed and critical discussion of the available experimental data on the emerging biological functions of NLRC5 in innate immune responses in men and mice. Better awareness of the multiple roles of NLRC5 will help to define its overall contribution to immune responses and cancer.
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Specialty section: This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology
Edited by: Uday Kishore, Brunel University London, UK
Reviewed by: Bastian Opitz, Charité, Germany; Tom Peter Monie, University of Cambridge, UK
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.00150