Role of angiotensin in renal sympathetic activation in nephrotic syndrome

Department of Internal Medicine, University of Iowa College of Medicine; and Veterans Administration Medical Center, Iowa City, Iowa 52242 The effect of type 1 angiotensin II receptor antagonist treatment (losartan) on cardiac baroreflex regulation of renal sympathetic nerve activity (RSNA) and rena...

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Published inAmerican journal of physiology. Regulatory, integrative and comparative physiology Vol. 274; no. 3; pp. 808 - R813
Main Authors Sanchez-Palacios, Manuel, Jones, Susan Y, Dibona, Gerald F
Format Journal Article
LanguageEnglish
Published United States 01.03.1998
Subjects
Angiotensin II - physiology
Animals
Baroreflex
Blood Pressure
Body Weight
Heart Rate
Infusions, Intravenous
Injections, Intraventricular
Kidney - physiopathology
Losartan - administration & dosage
Losartan - pharmacology
Male
Natriuresis
Nephrotic Syndrome - physiopathology
Pressoreceptors - physiology
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1
Receptor, Angiotensin, Type 2
Receptors, Angiotensin - physiology
Sympathetic Nervous System - physiology
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Summary:Department of Internal Medicine, University of Iowa College of Medicine; and Veterans Administration Medical Center, Iowa City, Iowa 52242 The effect of type 1 angiotensin II receptor antagonist treatment (losartan) on cardiac baroreflex regulation of renal sympathetic nerve activity (RSNA) and renal sodium handling in rats with nephrotic syndrome was examined. After intravenous losartan administration, with arterial pressure normalized by intravenous methoxamine, basal RSNA was decreased 14 ± 3% in arterial baroreceptor-intact rats and by 21 ± 5% in arterial baroreceptor-denervated rats. Intracerebroventricular losartan, which did not affect arterial pressure, decreased basal RSNA activity by 15 ± 1%. Both intravenous and intracerebroventricular losartan augmented the renal sympathoinhibitory response to acute volume loading, and this was associated with an enhanced natriuretic response to the acute volume load. In nephrotic syndrome, acute losartan administration improved cardiac baroreflex regulation of RSNA, which was associated with improved ability to excrete acute sodium loads. losartan; renal sympathetic nerve activity; cardiac baroreflex; sodium
ISSN:0363-6119
0002-9513
1522-1490
DOI:10.1152/ajpregu.1998.274.3.r808