Endothelial function is impaired in patients with primary antiphospholipid syndrome

• Published in: Thrombosis research Vol. 118; no. 4; pp. 455 - 461
• Main Authors: Štalc, Monika, Poredoš, Pavel, Peternel, Polona, Tomšič, Matija, Šebeštjen, Miran, Kveder, Tanja
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 2006; Elsevier Science
• Subjects: Administration, Oral; Adult; Aged; Anticoagulants - administration & dosage; Antiphospholipid Syndrome - drug therapy; Antiphospholipid Syndrome - physiopathology; Atherosclerosis; Biological and medical sciences; Blood and lymphatic vessels; Brachial Artery - physiopathology; Cardiology. Vascular system; Cardiovascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Endothelial function; Endothelium, Vascular - physiopathology; Female; Fibrinogen - analysis; Flow mediated dilation of brachial artery; Humans; Intercellular Adhesion Molecule-1 - blood; Male; Medical sciences; Middle Aged; Nitroglycerin - pharmacology; Pharmacology. Drug treatments; Primary antiphospholipid syndrome; Reproducibility of Results; Risk Factors; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Vascular Cell Adhesion Molecule-1 - blood; Vasodilation; Vasodilator agents. Cerebral vasodilators; GTN; ACE; APS; vWF; β2GPI; aCL; Endothelial function; sVCAM-1; sICAM-1; HDL; TF; LA; LDL; Primary antiphospholipid syndrome; Atherosclerosis; PAI-1; Flow mediated dilation of brachial artery; aPL; FMD; EC; t-PA; ELISA; Antianginal agent; Coronary vasodilator agent; Autoimmune disease; Cardiovascular disease; Hemopathy; t-Plasminogen activator; Vascular disease; Nitroglycerin; Organic nitrate; Fibrinogen; Complication; Thromboembolism; Human; Immunopathology; Antiphospholipid antibody syndrome; Serine endopeptidases; Intercellular adhesion molecule 1; Enzyme; Brachial artery; D dimer; Thrombosis; Embolism; Peptidases; Platelet; Risk factor; Hydrolases
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2005.09.005

The aim of this study was to evaluate endothelial function in patients with primary antiphospholipid syndrome (PAPS). Flow mediated (FMD) and glyceryl trinitrate (GTN) induced dilation of the right brachial artery were studied in 25 patients with PAPS and 25 controls matched by age, sex and conventional risk factors for atherosclerosis. Fibrinogen, D-dimer, adhesion molecules, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) antigens and activities were measured. Mean (SD) FMD was significantly lower in PAPS than in controls (8 ± 5% vs. 15 ± 6%, P < 0.001); GTN-induced dilation did not differ between the groups. There was a correlation between the baseline diameter of the brachial artery and duration of the disease (− 0.56, P < 0.05) and between GTN induced dilation and duration of the disease (0.51, P < 0.05). Concentrations of vascular cell adhesion molecule-1 ( P < 0.001), intracellular adhesion molecule-1 ( P < 0.001) and fibrinogen ( P < 0.05) were higher in patients than in controls but no differences were observed for D-dimer, t-PA and PAI-1 antigens and activities. There was correlation between concentration of vascular cell adhesion molecule-1 and FMD (− 0.35, P < 0.05) and between intracellular adhesion molecule-1 and FMD (− 0.41, P < 0.05). This study shows that endothelial function is impaired in patients with primary APS, possibly contributing to accelerated atherosclerosis and thromboembolic complications in these patients.