New Mechanisms of ECM Production during Wound Healing: A Role for Parathyroid Hormone 2 Receptor Signaling

Extracellular matrix deposition is required for wound healing. Studies by Sato et al. reveal a role for parathyroid hormone 2 receptor (PTH2R) in extracellular matrix production in wounds. Deficiencies in PTH2R or its ligand tuberoinfundibular peptide of 39 residues (TIP39) delayed repair, and TIP39...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 137; no. 8; pp. 1617 - 1619
Main Author Wilgus, Traci A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2017
Subjects
Animals
Extracellular Matrix - metabolism
Humans
Keratinocytes - metabolism
Keratinocytes - pathology
Receptor, Parathyroid Hormone, Type 1 - metabolism
Signal Transduction
Wound Healing - physiology
Wounds and Injuries - metabolism
Wounds and Injuries - pathology
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Summary:Extracellular matrix deposition is required for wound healing. Studies by Sato et al. reveal a role for parathyroid hormone 2 receptor (PTH2R) in extracellular matrix production in wounds. Deficiencies in PTH2R or its ligand tuberoinfundibular peptide of 39 residues (TIP39) delayed repair, and TIP39 treatment accelerated healing. TIP39-PTH2R signaling induced decorin expression, which may explain the beneficial effects of PTH2R signaling on healing. These studies identify a novel role for PTH2R signaling in extracellular matrix production.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Commentary-2
ObjectType-Feature-4
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ObjectType-Review-1
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ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2017.05.001