Spontaneous intramural duodenal hematoma in type 2B von Willebrand disease

• Published in: World journal of gastroenterology : WJG Vol. 19; no. 41; pp. 7205 - 7208
• Main Authors: Eichele, Derrick D, Ross, Meredith, Tang, Patrick, Hutchins, Grant F, Mailliard, Mark
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Co., Limited 07.11.2013
• Subjects: Abdominal Pain - etiology; Acute Disease; Blood Transfusion; Case Report; Coagulants - therapeutic use; Combined Modality Therapy; Decompression; Duodenal Diseases - diagnosis; Duodenal Diseases - etiology; Duodenal Diseases - therapy; Duodenal Obstruction - etiology; Endoscopy, Digestive System; Endosonography; Factor VIII - therapeutic use; Hematoma - diagnosis; Hematoma - etiology; Hematoma - therapy; Humans; Male; Nausea - etiology; Pancreatitis - etiology; Parenteral Nutrition, Total; Tomography, X-Ray Computed; Treatment Outcome; Vomiting - etiology; von Willebrand Disease, Type 2 - complications; von Willebrand Disease, Type 2 - diagnosis; von Willebrand Disease, Type 2 - therapy; Young Adult; von Willebrand disease; Duodenal hematoma
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v19.i41.7205

Intramural duodenal hematoma is a rare cause of a proximal gastrointestinal tract obstruction. Presentation of intramural duodenal hematoma most often occurs following blunt abdominal trauma in children, but spontaneous non-traumatic cases have been linked to anticoagulant therapy, pancreatitis, malignancy, vasculitis and endoscopy. We report an unusual case of spontaneous intramural duodenal hematoma presenting as an intestinal obstruction associated with acute pancreatitis in a patient with established von Willebrand disease, type 2B. The patient presented with abrupt onset of abdominal pain, nausea, and vomiting. Computed tomography imaging identified an intramural duodenal mass consistent with blood measuring 4.7 cm × 8.7 cm in the second portion of the duodenum abutting on the head of the pancreas. Serum lipase was 3828 units/L. Patient was managed conservatively with bowel rest, continuous nasogastric decompression, total parenteral nutrition, recombinant factor VIII (humateP) and transfusion. Symptoms resolved over the course of the hospitalization. This case highlights an important complication of an inherited coagulopathy.