Fatty liver is an independent risk factor for gallbladder polyps

Gallbladder polyps (GBPs) are known to be associated with obesity and metabolic diseases. However, to date, the relationship between GBPs and abnormal body fat distribution, such as fatty liver, visceral obesity, or sarcopenia, has not yet been established. To evaluate whether GBPs are associated wi...

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Published inWorld journal of gastroenterology : WJG Vol. 26; no. 44; pp. 6979 - 6992
Main Authors Ahn, Dong-Won, Jeong, Ji Bong, Kang, Jinwoo, Kim, Su Hwan, Kim, Ji Won, Kim, Byeong Gwan, Lee, Kook Lae, Oh, Sohee, Yoon, Soon Ho, Park, Sang Joon, Lee, Doo Hee
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 28.11.2020
Subjects
Adult
Body Mass Index
Case Control Study
Fatty Liver
Female
Gallbladder Diseases - diagnostic imaging
Gallbladder Diseases - epidemiology
Humans
Male
Middle Aged
Retrospective Studies
Risk Factors
Sarcopenia
Gallbladder polyp
Body fat distribution
Fatty liver
Risk factors
Visceral obesity
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Summary:Gallbladder polyps (GBPs) are known to be associated with obesity and metabolic diseases. However, to date, the relationship between GBPs and abnormal body fat distribution, such as fatty liver, visceral obesity, or sarcopenia, has not yet been established. To evaluate whether GBPs are associated with fatty liver, visceral obesity, or sarcopenia. We retrospectively reviewed the medical records of subjects who underwent various laboratory tests, body composition measurement with a non-invasive body composition analyzer, and abdominal ultrasonography during health checkups. A total of 1405 subjects with GBPs were compared with 2810 age- and sex-matched controls. The mean age of the subjects was 46.8 ± 11.7 years, and 63.8% were male. According to multiple logistic regression analysis, the presence of fatty liver [odds ratio (OR) 1.413; 95% confidence interval (CI) 1.218-1.638; < 0.001] was an independent risk factor for GBP, together with low levels of alanine aminotransferase (OR 0.993; 95%CI 0.989-0.996; < 0.001). Additionally, fatty liver showed both independent (OR 1.629; 95%CI, 1.335-1.988; < 0.001) and dose-dependent (moderate to severe fatty liver; OR 2.137; 95%CI, 1.662-2.749; < 0.001) relationship with large GBPs (≥ 5 mm). The presence of sarcopenia and high visceral fat area were not significantly associated with GBPs. Fatty liver was found to be closely associated with GBPs irrespective of sarcopenia and visceral obesity.
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Corresponding author: Ji Bong Jeong, MD, PhD, Associate Professor, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, 20 Borame-ro 5-gil, Dongjak-gu, Seoul 07061, South Korea. jibjeong@snu.ac.kr
Author contributions: Ahn DW planned and design the study, performed acquisition, analysis, and interpretation of data, drafted the manuscript, made critical revisions related to important intellectual content, and approved the manuscript; Jeong JB planned and design the study, performed acquisition, analysis, and interpretation of data, made critical revisions related to important intellectual content, and approved the manuscript; Kang J and Kim SH performed acquisition, analysis, and interpretation of data; Oh S, Kim JW, Kim BG and Lee KL performed analysis and interpretation of data, made critical revisions related to important intellectual content, and approved the manuscript; Yoon SH performed imaging analysis, reviewed imaging of computed tomography, and finally confirmed the results of the review; Park SJ and Lee DH performed imaging analysis and reviewed imaging of computed tomography.
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v26.i44.6979