Lack of Association between Gene Polymorphism of Transporters Associated with Antigen Processing and Allergic Rhinitis in a Japanese Population

• Published in: Annals of otology, rhinology & laryngology Vol. 111; no. 5; pp. 460 - 463
• Main Authors: Takeuchi, Kazuhiko, Yuta, Atsushi, Abe, Saori, Majima, Yuichi, Masuda, Sawako, Sakakura, Yasuo
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.05.2002; Annals Publishing Compagny; SAGE PUBLICATIONS, INC
• Subjects: Adolescent; Adult; Age Factors; Alleles; ATP-Binding Cassette Sub-Family B Member 2; ATP-Binding Cassette Transporters - genetics; Biological and medical sciences; DNA Primers - genetics; Electrophoresis, Agar Gel; Female; Genetic Predisposition to Disease; Genotype; Heterozygote; Homozygote; Humans; Japan; Major Histocompatibility Complex; Male; Medical sciences; Molecular Epidemiology; Mutation; Non tumoral diseases; Otorhinolaryngology. Stomatology; Polymerase Chain Reaction; Polymorphism, Genetic; Rhinitis, Allergic, Perennial - epidemiology; Rhinitis, Allergic, Perennial - genetics; Sex Factors; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology; Asia; Japan; allergy; gene polymorphism; TAP1; amplification refractory mutation system polymerase chain reaction; Human; Allergy; Nose disease; Rhinitis; Risk factor; ENT disease; Genetics; Case control study; Epidemiology; Public health; Polymorphism
• ISSN: 0003-4894; 1943-572X
• DOI: 10.1177/000348940211100512

Gene products of TAP1 and TAP2 (transporters associated with antigen processing) are involved in antigen presentation. It has been reported that polymorphisms in the TAP1 gene are associated with atopy in Tunisians. We designed a case-control study to investigate the potential association of polymorphisms of the TAP1 gene with allergic rhinitis in a Japanese population. We used the amplification refractory mutation system polymerase chain reaction to characterize TAP1 gene polymorphisms in 60 unrelated Japanese patients with allergic rhinitis and 62 healthy control subjects. There was no significant difference in the distribution of TAP1 alleles between the patient group and the control group. These findings suggest that the TAP1 gene is not primarily involved in susceptibility to allergic rhinitis in the Japanese population.