Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment

• Published in: Journal of polymers and the environment Vol. 26; no. 6; pp. 2281 - 2289
• Main Authors: Floriano, Juliana Ferreira, de Barros, Natan Roberto, Cinman, José Luiz Ferreira, da Silva, Rosangela Gonçalves, Loffredo, Augusto Villela, Borges, Felipe Azevedo, Norberto, Ana Maria Queiros, Chagas, Ana Laura Destro, Garms, Bruna Cambraia, de Oliveira Graeff, Carlos Frederico, Herculano, Rondinelli Donizetti
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2018; Springer Nature B.V
• Subjects: Addition polymerization; Adenocarcinoma; Angiogenesis; Anti-inflammatory agents; Arthritis; Biocompatibility; Biological activity; Biological materials; Chemistry; Chemistry and Materials Science; Drug delivery; Drug delivery systems; Environmental Chemistry; Environmental Engineering/Biotechnology; Erythrocytes; Industrial Chemistry/Chemical Engineering; Inflammation; Ketoprofen; Latex; Materials Science; Mechanical properties; Membranes; Natural rubber; Original Paper; Permeability; Physicochemical properties; Polymer Sciences; Polymers; Porosity; Rheumatoid arthritis; Rubber; Side effects; Surface stability; Tensile tests; Tissue engineering; Transdermal medication; Water vapor; Biomaterial; Transdermal drug delivery system; Anti-inflammatory; Ketoprofen; Natural rubber latex
• ISSN: 1566-2543; 1572-8919
• DOI: 10.1007/s10924-017-1127-x

Ketoprofen is an analgesic with potent anti-inflammatory activity against acute inflammation, subacute inflammation, for the acute and long-term treatment of various inflammatory pathologies, as rheumatoid arthritis and colonic adenocarcinoma. In order to minimize the incidence of systemic events related to ketoprofen, the transdermal drug delivery system development has been most important. The advantages of using natural rubber latex membranes include not only the reduction of adverse systemic events, but also the suitability of the low cost of the material together with its physicochemical properties such as flexibility, mechanical stability, surface porosity and water vapor permeability, and besides being a biocompatible material also presents biological activity to stimulate the angiogenesis, being able to be used in tissue repair. This study demonstrated that ketoprofen was successfully incorporated into natural latex membranes for drug delivery. FTIR indicated that the drug did not interact chemically with the membrane. Moreover, the natural latex membranes released 60% of the ketoprofen incorporated in 50 h. SEM images indicated that a portion of the drug was present on the membrane surface, being this portion responsible for the burst release. The tensile tests showed that the addition of the drug into the natural latex membrane did not influence on the polymer mechanical behavior. In addition, drug-natural latex membranes presented no red blood cell damaging effects. Our data shows that the ketoprofen loaded natural latex membranes is a promising system for sustained drug delivery which can be used to minimize the adverse side effects of high dose systemic drug delivery.