A randomized cross-over short-term study on the short-term effects of a zinc-lactate containing mouthwash against oral malodour

• Published in: Journal of breath research Vol. 13; no. 2; pp. 26005 - 26016
• Main Authors: Jervøe-Storm, Pia-Merete, Schulze, Hendrik, Jepsen, Søren
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 01.03.2019
• Subjects: Adult; Cross-Over Studies; Dental Plaque - diagnosis; Double-Blind Method; Drinking water; Female; Halitosis - drug therapy; Humans; Hydrogen Sulfide - analysis; Lactates - pharmacology; Male; Middle Aged; Mouth - pathology; Mouthwashes - chemistry; Mouthwashes - therapeutic use; oral malodour; organoleptic score; patient reported outcomes; Sensation - drug effects; Sulfhydryl Compounds - analysis; Sulfides - analysis; Surveys and Questionnaires; Time Factors; volatile-sulphur-compounds; Volatilization; Young Adult; Zinc - pharmacology; zinc-lactate
• ISSN: 1752-7163; 1752-7155; 1752-7163
• DOI: 10.1088/1752-7163/aaf401

Aim: This randomized controlled cross-over-design-study investigated short-term effects on oral malodour of a zinc-lactate-containing mouthwash. Materials and Methods: Sixteen subjects (18-65 years) with an organoleptic score (OLS) ≥2 were included. Following rinses were used: (A) a zinc-lactate-containing mouthwash (10 ml/30 s); (B) a zinc-lactate-containing mouthwash (15 ml/60 s); (C) a rinse without zinc-lactate (3 droplets/10 ml tap water/30 s) and (D) tap water (10 ml/30 s). Each formulation was evaluated by two blinded examiners comparing OLS and three volatile-sulphur-compounds (VSC; H2S (hydrogen sulphide), CH3SH (methyl mercaptan) and (CH3)2S (dimethyl sulphide)) before, 1 and 3 h after rinsing. Subject's perception was investigated with a visual-analogue-scale. Linear mixed models were used to compare all parameters simultaneously with respect to the four treatment groups with a significance level < 0.05. Results: OLS was significantly reduced by A and B compared to C and D after 3 h (p < 0.006). The sum of the 3 VSCs as well as H2S alone were significantly reduced by rinses A and B after 1 and 3 h compared to rinses C and D (p < 0.05). Significant differences were found between the four rinses for 'Taste' (p = 0.003), for 'Change of mouth feeling' (p = 0.001), for 'Feeling of freshness' (p = 0.002) and for 'Effectiveness' (p = 0.002) in favour of A & B. Conclusion: A zinc-lactate-containing mouthwash reduced OLS and VSC over a period of 3 h with favourable patient reported outcomes.