Aptamers as recognition elements for label-free analytical devices

In spite of the impressive advances in aptasensing, the search for label-free devices for the detection of the aptamer-ligand interaction is still a challenge. This review highlights the advantages and the limitations of using label-free detection strategies and summarizes the state of the art in th...

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Bibliographic Details
Published inTrAC, Trends in analytical chemistry (Regular ed.) Vol. 27; no. 5; pp. 437 - 446
Main Authors de-los-Santos-Álvarez, Noemí, Lobo-Castañón, Marı´a Jesús, Miranda-Ordieres, Arturo J., Tuñón-Blanco, Paulino
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.05.2008
Elsevier Science
Subjects
Acoustic wave
Analytical chemistry
Aptamer
Aptasensor
Chemistry
Electrochemistry
Exact sciences and technology
Impedance
Label-free
Mass spectrometry
Microcantilever
Optical device
Spectrometric and optical methods
SPR, Surface-plasmon resonance
Acoustic wave
Microcantilever
Electrochemistry
Optical device
Aptamer
Impedance
Label-free
Aptasensor
Mass spectrometry
SPR, Surface-plasmon resonance
State of the art
Microsensor
Acoustic wave; Aptamer; Aptasensor; Electrochemistry; Impédance; Label- free; Mass spectrometry; Microcantilever; Optical device; SPR
Surface-plasmon resonance
Surface plasmon resonance
Review
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Summary:In spite of the impressive advances in aptasensing, the search for label-free devices for the detection of the aptamer-ligand interaction is still a challenge. This review highlights the advantages and the limitations of using label-free detection strategies and summarizes the state of the art in this field.
ISSN:0165-9936
1879-3142
DOI:10.1016/j.trac.2008.03.003