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Mann et al. (2018) use recombinant human tyrosinase to screen for novel inhibitors of pigmentation. They develop thiamidol, a new thiazolyl-resorcinol derivative, that is a submicromolar tyrosinase inhibitor and effective for treating solar lentigines. Thiamidol and established inhibitors of pigment...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 138; no. 7; pp. 1470 - 1472
Main Author Hornyak, Thomas J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2018
Subjects
Agaricales
Humans
Lentigo
Monophenol Monooxygenase
Pigmentation
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Summary:Mann et al. (2018) use recombinant human tyrosinase to screen for novel inhibitors of pigmentation. They develop thiamidol, a new thiazolyl-resorcinol derivative, that is a submicromolar tyrosinase inhibitor and effective for treating solar lentigines. Thiamidol and established inhibitors of pigmentation exhibit substantially different activities on human and mushroom tyrosinase, supporting use of the human enzyme in high-throughput screens.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Commentary-2
ObjectType-Feature-3
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ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2018.03.003