Draft Genome Sequences of Two Pyrazinamide-Resistant Clinical Isolates, Mycobacterium tuberculosis 13-4152 and 13-2459

We report draft genome sequences of two pyrazinamide (PZA)-resistant isolates, Mycobacterium tuberculosis 13-4152 and 13-2459. Isolate 13-4152 is PZA resistant, though it lacks mutations in known genes of PZA resistance. The comparative analysis of these genomes with those stored in GenBank revealed...

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Published inGenome announcements (Washington, DC) Vol. 3; no. 4
Main Authors Maslov, D A, Shur, K V, Bekker, O B, Zakharevich, N V, Zaichikova, M V, Klimina, K M, Smirnova, T G, Zhang, Y, Chernousova, L N, Danilenko, V N
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 02.07.2015
Subjects
Prokaryotes
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Summary:We report draft genome sequences of two pyrazinamide (PZA)-resistant isolates, Mycobacterium tuberculosis 13-4152 and 13-2459. Isolate 13-4152 is PZA resistant, though it lacks mutations in known genes of PZA resistance. The comparative analysis of these genomes with those stored in GenBank revealed unique mutations, which may elucidate new mechanisms of PZA resistance.
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ISSN:2169-8287
2169-8287
DOI:10.1128/genomeA.00758-15