Stereospecific interactions between chiral inorganic nanomaterials and biological systems
Chirality is ubiquitous in nature and plays mysterious and essential roles in maintaining key biological and physiological processes. As biological systems display high selectivity for chiral biomolecules, chiral bio-nanoscience has become a popular research field during the last decade. Homochirali...
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| Published in | Chemical Society reviews Vol. 49; no. 8; pp. 2481 - 253 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
21.04.2020
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Chirality is ubiquitous in nature and plays mysterious and essential roles in maintaining key biological and physiological processes. As biological systems display high selectivity for chiral biomolecules, chiral bio-nanoscience has become a popular research field during the last decade. Homochirality, as an essential attribute of natural compounds (
l
-amino acids,
d
-sugars,
etc.
), inspired the emergence of synthetic chiral nanomaterials, which in turn impacted their biological functions and fates. This review is a comprehensive overview of the interactions between chiral inorganic nanostructures and biosystems. We start with the recent progress in biocompatible chiral nanomaterials and focus on stereospecific biological interactions ranging from enantioselective reactions in applications such as sensing and catalysis to chirality-dependent controllable manipulation of cell behaviours and finally to enantiopure nanoplatforms for improved disease therapy. We also discuss the current challenges and future potential of these chiral nanotechnologies in biomedicine and bioengineering, provide strategies to overcome these barriers and offer a future perspective.
Chirality is ubiquitous in nature and plays mysterious and essential roles in maintaining key biological and physiological processes. |
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| Bibliography: | Dr Xueli Zhao received her PhD from Jiangnan University in 2018 under the supervision of Prof. Chuanlai Xu and Prof. Hua Kuang. Then she moved to Zhengzhou University and joined Laboratory of Functional Crystalline Molecular Materials. Her research interest focuses on design, synthesis of biocompatible metal nanoclusters for cancer theranostics, chiral nanomaterials manipulating cell behaviours. Dr Xiaoyuan (Shawn) Chen is a Senior Investigator and Chief of the Laboratory of Molecular Imaging and Nanomedicine (LOMIN) at the National Institute of Biomedical Imaging and Bioengineering (NIBIB), NIH. His current research interests include development of molecular imaging toolbox for better understanding of biology, early diagnosis of disease, monitoring therapy response, and guiding drug discovery/development. Dr Chen has published over 800 peer-reviewed papers (H-index = 139, total citations >68 000 based on Google Scholar) and numerous books and book chapters. He is the founding editor of journal "Theranostics" (2018 IF = 8.063). Dr Shuang-Quan Zang received his PhD in Chemistry from Nanjing University in 2006 under the supervision of Prof. Qing-Jin Meng. Then he moved to The Chinese University of Hong Kong and worked with Prof. Thomas C. W. Mak in Department of Chemistry and Center of Novel Functional Molecules as a postdoctoral fellow. In 2008, he joined Zhengzhou University and was awarded with "Distinguished Professor of Henan Province" in 2015. His research focuses on atomically precise metal clusters and cluster-assembled materials, metal nanoclusters for cancer diagnosis and therapy, functional metal-organic frameworks. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/d0cs00093k |