Acute quadriplegic myopathy following autologous peripheral blood stem cell transplantation for breast cancer

Autologous peripheral blood stem cell transplantation (APSCT) is increasingly used in the treatment of breast cancer. We report a patient who experienced septic shock, and after treatment with antibiotics, high-dose corticosteroids and mechanical ventilation due to respiratory insufficiency, develop...

Full description

Saved in:
Bibliographic Details
Published inBone marrow transplantation (Basingstoke) Vol. 23; no. 8; pp. 835 - 837
Main Authors SAMUELSSON, J, ZACKRISSON, H, TOKICS, L, LJUNGMAN, P, LIDBRINK, E, PIRCHER, P, LARSSON, L
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.04.1999
Subjects
Acute Disease
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antibiotics
Autografts
Biological and medical sciences
Biopsy
Blood
Bone marrow, stem cells transplantation. Graft versus host reaction
Breast cancer
Breast Neoplasms - therapy
Corticoids
Corticosteroids
Female
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Mechanical ventilation
Medical sciences
Medicin och hälsovetenskap
Middle Aged
Muscles
Myopathy
Paralysis
Peripheral blood
Quadriplegia - etiology
Septic shock
Stem cell transplantation
Stem cells
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation
Transplantation, Autologous
Human
Corticosteroid
Nervous system diseases
Toxicity
Stem cell
Hematopoietic cell
Malignant tumor
Case study
Mammary gland diseases
Striated muscle disease
Autograft
Chemotherapy
Treatment
Myosin
Graft
Adult
Complication
Female
Mammary gland
Myopathy
Online AccessGet full text

Cover

More Information
Summary:Autologous peripheral blood stem cell transplantation (APSCT) is increasingly used in the treatment of breast cancer. We report a patient who experienced septic shock, and after treatment with antibiotics, high-dose corticosteroids and mechanical ventilation due to respiratory insufficiency, developed quadriplegia. Electroneurophysiological examination, as well as a muscle biopsy, showed a typical picture of acute quadriplegic myopathy with loss of thick filament proteins. This is, to the best of our knowledge, the first reported case of this complication following APSCT.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1701661